Skip to main content

Table 3 Comparative mean (±SD) kinetic parameters of (−) ABZ-SO and (+) ABZ-SO in goats and sheep following intravenous administrations at a dose of 5 mg/kg (n = 8)

From: Comparative pharmacokinetics and bioavailability of albendazole sulfoxide in sheep and goats, and dose-dependent plasma disposition in goats

Parameters

Goat

Sheep

(−) ABZ-SO

(+) ABZ-SO

(−) ABZ-SO

(+) ABZ-SO

T1/2λz (h)

3.66 ± 0.66*

8.03 ± 1.67

3.98 ± 0.64*

9.36 ± 2.23

Cmax (μg/mL)

2.32 ± 0.40

2.11 ± 0.33

2.33 ± 0.27

1.95 ± 0.29

Tlast (h)

15.43 ± 1.51*

20.57 ± 4.28

17.00 ± 2.83*

30.00 ± 3.70

AUClast (μg.h/mL)

11.73 ± 2.43*

18.45 ± 5.62

11.96 ± 1.50*

20.53 ± 3.90

AUCMlast (μg.s2/mL)

51.33 ± 16.00

135.35 ± 62.98

55.53 ± 9.48*

186.82 ± 49.46

Cl (L/h/kg)

0.42 ± 0.10*

0.24 ± 0.06

0.40 ± 0.06

0.24 ± 0.06

MRTlast (h)

4.29 ± 0.57*

7.07 ± 1.20

4.63 ± 0.38*

8.98 ± 1.44

Vdss (L/kg)

2.05 ± 0.24

2.53 ± 0.41

2.23 ± 0.27

2.47 ± 0.30

  1. T 1/2λz terminal half-life; C max peak plasma concentration; T last time to last detectable plasma concentration; AUC last area under the (zero moment) curve from time 0 to the last detectable concentration; AUCM area under the moment curve from time 0 to t last detectable concentration; Cl clearance of drug; MRT last mean residence time; Vdss: volume of distribution at steady-state
  2. *Differences between the enantiomers in the same animal species (P < 0.05)