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Table 2 Comparative mean (±SD) kinetic parameters of ABZ–SO and ABZ–SO2 in goats and sheep following intravenous administrations at a dose of 5 mg/kg (n = 8)

From: Comparative pharmacokinetics and bioavailability of albendazole sulfoxide in sheep and goats, and dose-dependent plasma disposition in goats

Parameters

Goat

Sheep

ABZ-SO

ABZ-SO2

ABZ-SO

ABZ-SO2

T1/2λz (h)

5.43 ± 0.89*

3.53 ± 0.81*

6.57 ± 0.73

11.43 ± 9.41

Cmax (μg/mL)

-

0.62 ± 0.21

-

0.46 ± 0.05

C0 (μg/mL)

10.84 ± 1.81

-

10.86 ± 1.82

-

Tmax (h)

-

15.00 ± 6.48*

-

8.50 ± 3.34

Tlast (h)

21.00 ± 4.14*

25.00 ± 10.56

30.00 ± 3.70

31.00 ± 2.83

AUClast (μg.h/mL)

34.10 ± 5.31*

10.49 ± 4.26

39.15 ± 5.59

11.00 ± 0.78

AUCMlast (μg.h2/mL)

201.91 ± 58.84*

133.34 ± 65.25

293.46 ± 64.66

155.96 ± 17.30

Cl (L/h/kg)

0.14 ± 0.03

-

0.13 ± 0.02

-

MRTlast (h)

5.81 ± 0.86*

12.31 ± 4.95

7.44 ± 1.03

14.18 ± 1.28

Vdss (L/kg)

0.94 ± 0.09

-

1.04 ± 0.14

-

  1. T 1/2λz terminal half-life; C max peak plasma concentration; C 0 plasma concentration at time 0; T max time to reach peak plasma concentration; T last time to last detectable plasma concentration; AUC last area under the (zero moment) curve from time 0 to the last detectable concentration; AUCM area under the moment curve from time 0 to t last detectable concentration; Cl clearance of drug; MRT last mean residence time; Vd ss volume of distribution at steady-state
  2. *The parameters in goats are significantly different from those in sheep (*P < 0.05)