Comparative pharmacokinetics and bioavailability of albendazole sulfoxide in sheep and goats, and dose-dependent plasma disposition in goats

Table 1 Validation of analytical method used for determination of ABZ, ABZ-NH₃, ABZ-SO and ABZ-SO₂ concentrations in plasma

	ABZ-NH₃	ABZ-SO	ABZ-SO₂	ABZ
LOD (μg/ml)	0.015	0.016	0.016	0.017
LOQ (μg/ml)	0.042	0.045	0.045	0.050
Range of linearity (μg/ml)	0.05-20	0.05-20	0.05-20	0.05-20
Linearity (r ²)	0.997	0.999	0.998	0.996
Recovery (%)	63.69 (5.42)	94.10 (6.39)	91.90 (4.88)	69.29 (6.21)
Coefficient of variation (%)	6.89	5.35	6.33	7.75
Retention times (min)	5.37	5.77	6.81	9.95

LOD limit of detection, LOQ limit of quantification. Values in the brackets represent the coefficient of variations for the recovery assays, r: correlation coefficient

ISSN: 1746-6148