Daily rectal temperatures (in °C) measured in 27 horses before each injection (1) and on three consecutive days. There was a significant transient increase in the temperature on the first day after injection (Tukey-Kramer Multiple Comparison Test). The center horizontal line of the box plot marks the median of the sample. The edges of the box mark the first and third quartiles. The dotted lines define the 75th percentile plus 1.5 times the interquartile range (IQR) and the 25th percentile minus 1.5 times IQR. The singular dots represent the outside values. *** Significant difference (p ≤ 0.0001).