| |
Day 0
|
Day 1
|
Day 2 to 9
|
Day 10
|
|---|
|
Time (T)
|
Initial visit
|
T0*
|
T1a
|
T1 + 3 hours (±0.5 hours)
|
T1 + 8 hours (±1 hours)
|
T1 + 22 hours (±2 hours)
|
T2b
|
T2 + 4 hours (±2 hours)
| |
Final visit (±2 days)
|
|
Description
|
V1
| | |
V2
|
V3
|
V4
| |
V5
| |
VF
|
|
Location
|
Clinic
|
Clinic
|
Clinic
|
Clinic
|
Clinic
|
Clinic
|
Clinic
|
Clinic
|
Home
|
Clinic
|
|
Activity
| |
Administer s.c. injection Anaesthesia induction
|
Extubation
| | | |
First oral dose
| |
Once-daily oral dosesc
| |
- s.c.: subcutaneous; V: visit; VF: final visit.
-
*The s.c. first drug administration was close to the time of anaesthetic induction (T0).
-
aTime of extubation if the cat was intubated during anaesthesia or return of palpebral reflex if not intubated (T1).
-
bThe first tablet was administered by the dispenser approximately 24 hours after the s.c. administration (T2).
-
cTablets were administered from Day 2 to the day preceding the VF by the owner. The total duration of oral dosing was 9 days (range, 7–11 days).
