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Table 4 Lesions in intestinal lymph nodes, oGALT and small intestine of the MAP-inoculated goats at necropsy: macroscopic and histological lesions and MAP detection by IHC

From: Characterization of a caprine model for the subclinical initial phase of Mycobacterium avium subsp. paratuberculosis infection

Group Anim. No. Mesenteric and ileocolic LNN oGALT (e.g. JPP, #of sites examined = 7) Small intestine (#of sites examined = 5) Lesion cat. summary
Macro Histo MAP IHC Lesion cat. LNN Macro Histo MAP IHC #of sites affected Lesion cat. oGALT Macro Histo MAP IHC #of sites affected Lesion cat. intestine
V1 7 , e G 2 III - - 0 0 I - - 0 0 I III
8 , e G, gInf 2 III mf , D 2 7 III , E mf +++ 2 4 III III
9 , e G, gInf 1 II mf , C 2 5 III , S mf ++ 0 4 III III
10 , f G, gInf 1 III mf, C 1 4 III , S mf + 2 4 III III
11 , e G, gInf 1 III f/mf, C/A 0 2 II - f + 0 1 II II
12 , e G 1 III - - 0 0 I - - 0 0 I III
13 - gInf 1 II f/mf, B 0 1 II , MF mf + 0 2 II II
V2 14a , e G, gInf 1 III f, C 0 3 II - - 0 0 I II
15 - - 0 I mf, C 0 1 II , MF - 0 0 I II
16a , e G, gInf 1 III mf, B 0 3 II , E mf ++ 0 4 III III
17a , e G, gInf 1 III mf, C 0 1 II - - 0 0 I II
18 , e G, gInf 2 III mf, C 0 3 II - - 0 0 I II
19 , e G, gInf 2 III mf/d, C 0 6 III , S mf ++ 0 4 III III
20a , f G, gInf 1 II - - 0 0 I - - 0 0 I II
V3 27 , f G 0 II mf, C/A 0 5 III , S, MF f + 0 1 II II
28 , e G, gInf 1 II mf, C 0 1 II , MF f ++ 0 3 III II
29 , f G, gInf 1 II f, C 0 2 II - - 0 0 I II
30 , f G, gInf 1 II mf, C 0 4 III - - 0 0 I II
31 - gInf 0 II - - 0 0 I - - 0 0 I II
32 , e G, gInf 1 III f, C 0 2 II - f ++ 0 1 II II
V4 33 , e G, gInf 1 III f/mf, C/A 0 2 II , MF mf + 0 1 II II
34 - - 0 I mf, C 0 1 II - f + 0 2 II II
35 , e G, gInf 1 III mf, C 0 7 III , MF mf ++ 0 4 III III
36b - - 0 I mf, C 0 4 III - f + 0 1 II II
37 , e G, gInf 1 III mf, D 2 4 III , MF mf +/++ 1 4 III III
38 , e G, gInf 1 III - - 0 0 I - - 0 0 I III
39 - - 0 I - - 0 0 I - - 0 0 I I
  1. paratuberculous lesion; − no paratuberculous lesion; LNN lymph nodes; G granuloma; gInf granulomatous infiltrate; MAP IHC MAP detected by IHC; nd not done; anecropsy at 37–39 wpi; bnecropsy at 35 wpi; 0 no MAP; 1 paucibacillary; 2 multibacillary; f focal; mf multifocal; e extensive; A-D type of histological lesion (see text); +, ++, +++ mild, moderate, severe granulomatous infiltrates; E entire small intestine with thickened intestinal wall and corrugated mucosa; S segments of small intestine with thickened intestinal wall and corrugated mucosa; MF 0.5 – 2 cm thickening of the intestinal mucosa with central depression; lesion categories: I - no lesions; II – mild lesions; III - severe lesions.