|
Group
|
Anim. No.
|
Mesenteric and ileocolic LNN
|
oGALT (e.g. JPP, #of sites examined = 7)
|
Small intestine (#of sites examined = 5)
|
Lesion cat. summary
|
|---|
|
Macro
|
Histo
|
MAP IHC
|
Lesion cat. LNN
|
Macro
|
Histo
|
MAP IHC
|
#of sites affected
|
Lesion cat. oGALT
|
Macro
|
Histo
|
MAP IHC
|
#of sites affected
|
Lesion cat. intestine
|
|---|
|
V1
|
7
| ✓, e |
G
|
2
|
III
|
-
|
-
|
0
|
0
|
I
|
-
|
-
|
0
|
0
|
I
|
III
|
|
8
| ✓, e |
G, gInf
|
2
|
III
| ✓ |
mf , D
|
2
|
7
|
III
| ✓, E |
mf +++
|
2
|
4
|
III
|
III
|
|
9
| ✓, e |
G, gInf
|
1
|
II
| ✓ |
mf , C
|
2
|
5
|
III
| ✓, S |
mf ++
|
0
|
4
|
III
|
III
|
|
10
| ✓, f |
G, gInf
|
1
|
III
| ✓ |
mf, C
|
1
|
4
|
III
| ✓, S |
mf +
|
2
|
4
|
III
|
III
|
|
11
| ✓, e |
G, gInf
|
1
|
III
| ✓ |
f/mf, C/A
|
0
|
2
|
II
|
-
|
f +
|
0
|
1
|
II
|
II
|
|
12
| ✓, e |
G
|
1
|
III
|
-
|
-
|
0
|
0
|
I
|
-
|
-
|
0
|
0
|
I
|
III
|
|
13
|
-
|
gInf
|
1
|
II
| ✓ |
f/mf, B
|
0
|
1
|
II
| ✓, MF |
mf +
|
0
|
2
|
II
|
II
|
|
V2
|
14a
| ✓, e |
G, gInf
|
1
|
III
| ✓ |
f, C
|
0
|
3
|
II
|
-
|
-
|
0
|
0
|
I
|
II
|
|
15
|
-
|
-
|
0
|
I
| ✓ |
mf, C
|
0
|
1
|
II
| ✓, MF |
-
|
0
|
0
|
I
|
II
|
|
16a
| ✓, e |
G, gInf
|
1
|
III
| ✓ |
mf, B
|
0
|
3
|
II
| ✓, E |
mf ++
|
0
|
4
|
III
|
III
|
|
17a
| ✓, e |
G, gInf
|
1
|
III
| ✓ |
mf, C
|
0
|
1
|
II
|
-
|
-
|
0
|
0
|
I
|
II
|
|
18
| ✓, e |
G, gInf
|
2
|
III
| ✓ |
mf, C
|
0
|
3
|
II
|
-
|
-
|
0
|
0
|
I
|
II
|
|
19
| ✓, e |
G, gInf
|
2
|
III
| ✓ |
mf/d, C
|
0
|
6
|
III
| ✓, S |
mf ++
|
0
|
4
|
III
|
III
|
|
20a
| ✓, f |
G, gInf
|
1
|
II
|
-
|
-
|
0
|
0
|
I
|
-
|
-
|
0
|
0
|
I
|
II
|
|
V3
|
27
| ✓, f |
G
|
0
|
II
| ✓ |
mf, C/A
|
0
|
5
|
III
| ✓, S, MF |
f +
|
0
|
1
|
II
|
II
|
|
28
| ✓, e |
G, gInf
|
1
|
II
| ✓ |
mf, C
|
0
|
1
|
II
| ✓, MF |
f ++
|
0
|
3
|
III
|
II
|
|
29
| ✓, f |
G, gInf
|
1
|
II
| ✓ |
f, C
|
0
|
2
|
II
|
-
|
-
|
0
|
0
|
I
|
II
|
|
30
| ✓, f |
G, gInf
|
1
|
II
| ✓ |
mf, C
|
0
|
4
|
III
|
-
|
-
|
0
|
0
|
I
|
II
|
|
31
|
-
|
gInf
|
0
|
II
|
-
|
-
|
0
|
0
|
I
|
-
|
-
|
0
|
0
|
I
|
II
|
|
32
| ✓, e |
G, gInf
|
1
|
III
| ✓ |
f, C
|
0
|
2
|
II
|
-
|
f ++
|
0
|
1
|
II
|
II
|
|
V4
|
33
| ✓, e |
G, gInf
|
1
|
III
| ✓ |
f/mf, C/A
|
0
|
2
|
II
| ✓, MF |
mf +
|
0
|
1
|
II
|
II
|
|
34
|
-
|
-
|
0
|
I
| ✓ |
mf, C
|
0
|
1
|
II
|
-
|
f +
|
0
|
2
|
II
|
II
|
|
35
| ✓, e |
G, gInf
|
1
|
III
| ✓ |
mf, C
|
0
|
7
|
III
| ✓, MF |
mf ++
|
0
|
4
|
III
|
III
|
|
36b
|
-
|
-
|
0
|
I
| ✓ |
mf, C
|
0
|
4
|
III
|
-
|
f +
|
0
|
1
|
II
|
II
|
|
37
| ✓, e |
G, gInf
|
1
|
III
| ✓ |
mf, D
|
2
|
4
|
III
| ✓, MF |
mf +/++
|
1
|
4
|
III
|
III
|
|
38
| ✓, e |
G, gInf
|
1
|
III
|
-
|
-
|
0
|
0
|
I
|
-
|
-
|
0
|
0
|
I
|
III
|
|
39
|
-
|
-
|
0
|
I
|
-
|
-
|
0
|
0
|
I
|
-
|
-
|
0
|
0
|
I
|
I
|
- ✓ paratuberculous lesion; − no paratuberculous lesion; LNN lymph nodes; G granuloma; gInf granulomatous infiltrate; MAP IHC MAP detected by IHC; nd not done; anecropsy at 37–39 wpi; bnecropsy at 35 wpi; 0 no MAP; 1 paucibacillary; 2 multibacillary; f focal; mf multifocal; e extensive; A-D type of histological lesion (see text); +, ++, +++ mild, moderate, severe granulomatous infiltrates; E entire small intestine with thickened intestinal wall and corrugated mucosa; S segments of small intestine with thickened intestinal wall and corrugated mucosa; MF 0.5 – 2 cm thickening of the intestinal mucosa with central depression; lesion categories: I - no lesions; II – mild lesions; III - severe lesions.
