TY - JOUR AU - Chang, Guangjun AU - Zhang, Kai AU - Xu, Tianle AU - Jin, Di AU - Seyfert, Hans-Martin AU - Shen, Xiangzhen AU - Zhuang, Su PY - 2015 DA - 2015/03/18 TI - Feeding a high-grain diet reduces the percentage of LPS clearance and enhances immune gene expression in goat liver JO - BMC Veterinary Research SP - 67 VL - 11 IS - 1 AB - The effects of feeding a high-grain (HG) diet on lipopolysaccharide (LPS) clearance and innate immune defence responses in the liver remain unclear. Therefore, we conducted the present study in which twelve female goats were randomly assigned to either a treatment group fed a HG diet (60% grain, n = 6) or a control group fed a low grain diet (LG; 40% grain, n = 6) for 6 weeks. Catheters were installed in the mesenteric, portal and hepatic veins, as well as one femoral artery of the goats, for determining blood flow and net clearance rate of LPS in the liver. Plasma and tissue samples were collected in the week 6 for analyzing pro-inflammatory cytokines, acute phase protein and biochemical parameters, as well as expression of genes involved in immune response. SN - 1746-6148 UR - https://doi.org/10.1186/s12917-015-0376-y DO - 10.1186/s12917-015-0376-y ID - Chang2015 ER -