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Table 3 Probability of target attainment (PTA) and breakpoints of cefquinome against H. parasuis with recommended regimens (2 mg/kg/24 h and 4 mg/kg/12 h)

From: In vitro dynamic pharmacokinetic/pharmacodynamic(PK/PD) modeling and PK/PD cutoff of cefquinome against Haemophilus parasuis

Drug regimens

PTA for T% > MIC = 61

PTA for T% > MIC = 71

Susceptibility breakpoint (mg/L)

1 mg/kg/12 h

76.87

72.52

0.3

2 mg/kg/12 h

82.19

80.63

0.6

4 mg/kg/12 h

85.79

84.37

1.3

6 mg/kg/12 h

86.46

85.88

1.9

8 mg/kg/12 h

87.64

86.76

2.6

16 mg/kg/12 h

90.03

88.55

5.2

2 mg/kg/24 h

44.79

28.18

0.06

4 mg/kg/24 h

61.77

43.52

0.15

8 mg/kg/24 h

76.91

61.6

0.3

16 mg/kg/24 h

81.25

77.21

0.6

32 mg/kg/24 h

86.06

82.21

1.2

60 mg/kg/24 h

86.64

84.74

2.2