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Table 3 Probability of target attainment (PTA) and breakpoints of cefquinome against H. parasuis with recommended regimens (2 mg/kg/24 h and 4 mg/kg/12 h)

From: In vitro dynamic pharmacokinetic/pharmacodynamic(PK/PD) modeling and PK/PD cutoff of cefquinome against Haemophilus parasuis

Drug regimens PTA for T% > MIC = 61 PTA for T% > MIC = 71 Susceptibility breakpoint (mg/L)
1 mg/kg/12 h 76.87 72.52 0.3
2 mg/kg/12 h 82.19 80.63 0.6
4 mg/kg/12 h 85.79 84.37 1.3
6 mg/kg/12 h 86.46 85.88 1.9
8 mg/kg/12 h 87.64 86.76 2.6
16 mg/kg/12 h 90.03 88.55 5.2
2 mg/kg/24 h 44.79 28.18 0.06
4 mg/kg/24 h 61.77 43.52 0.15
8 mg/kg/24 h 76.91 61.6 0.3
16 mg/kg/24 h 81.25 77.21 0.6
32 mg/kg/24 h 86.06 82.21 1.2
60 mg/kg/24 h 86.64 84.74 2.2