In vitro dynamic pharmacokinetic/pharmacodynamic(PK/PD) modeling and PK/PD cutoff of cefquinome against Haemophilus parasuis

Table 2 Pharmacodynamic analysis of data acquired from in vitro time-killing studies for cefquinome against H. parasuis

Parameter (units)	Value
Log E _max (cfu/mL)	−4.7
Log E ₀ (cfu/mL)	1.6
EC₅₀ (h)	48.9
T% > MIC (bacteriostatic) (h)	38.7
T% > MIC (bactericidal) (h)	60.9
T% > MIC (bacterial elimination) (h)	70.9
Slope (N)	4.7

Where E ₀ is the change in log₁₀ cfu/mL after 24 h incubation in the control sample compared to the initial inoculum. E _max is the difference in effect between the greatest amount of growth (as seen for the growth control, E ₀) and the greatest amount of kill. C _e is the T% > MIC in the effect compartment. EC ₅₀ is the T% > MIC value producing a 50% reduction in bacterial counts from the initial inoculum, and N is the Hill coefficient that describes the steepness of the T% > MIC–effect curve.

ISSN: 1746-6148