Seizure frequency and seizure days frequency of all dogs (A, B) and the two treatment groups, maintenance (C, D) and pulse treatment (E, F) group. The seizure frequency and seizure days frequency are displayed prior to any treatment, prior to levetiracetam treatment (Prior LEV), and while receiving levetiracetam (LEV). Central lines of the box represent the median, lower and upper limits of the box represent the 25th and 75th percentiles and whiskers represent the 10th and 90th percentiles. Mean values are denotated as +. (Friedman test, post-hoc Dunn’s multiple comparison test; *P < 0.05).