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Table 3 Medetomidine-midazolam-fentanyl – mean values with standard deviation

From: Influence of repeated anaesthesia on physiological parameters in male Wistar rats: a telemetric study about isoflurane, ketamine-xylazine and a combination of medetomidine, midazolam and fentanyl

Parameter Run Baseline Induction Non-surgical tolerance Surgical tolerance Wake-up Recovery
  (No. of animals) Mean ± SD Mean ± SD Mean ± SD Mean ± SD Mean ± SD Mean ± SD
SAP (mmHg) 1 (6) 117 ± 5.42 158 ± 19.28 160 ± 21.24 157 ± 23.24 101 ± 15.20 113 ± 9.43
2 (6) 111 ± 7.34 144 ± 19.22* 151 ± 24.77 151 ± 25.47 105 ± 15.15 113 ± 7.08
3 (6) 112 ± 9.32 153 ± 18.24 152 ± 23.21 147 ± 24.90* 101 ± 13.70 115 ± 7.90
4 (5) 116 ± 8.18 149 ± 19.24 157 ± 28.86 146 ± 20.77 102 ± 11.90 114 ± 11.13
5 (6) 115 ± 6.49 153 ± 19.81 154 ± 21.44 146 ± 25.10* 103 ± 10.03 117 ± 9.90
6 (5) 117 ± 11.54 150 ± 17.01 146 ± 14.86* 148 ± 26.76 109 ± 17.16* 121 ± 11.21*
DAP (mmHg) 1 (6) 89 ± 4.40 120 ± 15.38 112 ± 7.78 107 ± 12.31 76 ± 13.69 90 ± 11.00
2 (6) 84 ± 7.51 112 ± 10.63 106 ± 12.00 103 ± 12.22 81 ± 10.84 90 ± 6.40
3 (6) 84 ± 5.49 117 ± 12.26 108 ± 9.00 103 ± 11.24 77 ± 11.00 91 ± 9.09
4 (5) 89 ± 13.66 114 ± 6.48 111 ± 15.30 101 ± 6.64 76 ± 4.93 91 ± 13.87
5 (6) 87 ± 5.85 116 ± 9.81 112 ± 8.85 103 ± 9.61 78 ± 8.78 92 ± 10.43
6 (5) 89 ± 12.07 117 ± 10.93 110 ± 7.56 106 ± 10.62 84 ± 12.95 97 ± 11.12*
MAP (mmHg) 1 (6) 98 ± 2.90 132 ± 15.27 128 ± 10.61 123 ± 14.23 84 ± 13.90 98 ± 10.09
2 (6) 93 ± 6.90 123 ± 12.88* 121 ± 15.41 119 ± 15.59 89 ± 12.11 98 ± 6.27
3 (6) 93 ± 5.91 129 ± 12.90 123 ± 12.68 118 ± 14.39 85 ± 11.55 99 ± 8.38
4 (5) 98 ± 11.61 126 ± 9.62 126 ± 19.01 116 ± 10.48 84 ± 6.59 99 ± 12.78
5 (6) 96 ± 5.27 128 ± 12.79 126 ± 12.53 117 ± 14.16 86 ± 8.81 101 ± 9.98
6 (5) 98 ± 11.39 128 ± 12.03 122 ± 8.47 120 ± 15.02 93 ± 14.07* 105 ± 10.66*
PP (mmHg) 1 (6) 28 ± 8.01 38 ± 14.80 48 ± 18.77 51 ± 18.78 25 ± 6.32 23 ± 6.17
2 (6) 27 ± 5.94 33 ± 12.11 45 ± 16.81 48 ± 18.10 24 ± 6.08 23 ± 4.64
3 (6) 28 ± 7.98 36 ± 14.18 43 ± 18.11 44 ± 19.42* 24 ± 6.67 24 ± 5.03
4 (5) 27 ± 7.33 35 ± 16.25 46 ± 18.03 45 ± 16.88 27 ± 9.47 23 ± 5.29
5 (6) 28 ± 6.38 37 ± 11.88 42 ± 14.75* 43 ± 17.89* 25 ± 5.78 24 ± 5.08
6 (5) 28 ± 7.29 33 ± 11.90* 36 ± 13.39* 42 ± 19.92* 25 ± 7.30 24 ± 6.96
HR (bpm) 1 (6) 289 ± 23.42 285 ± 37.92 211 ± 16.99 197 ± 19.63 249 ± 19.49 275 ± 15.28
2 (6) 274 ± 14.20 285 ± 45.73 214 ± 14.44 195 ± 15.42 255 ± 23.43 276 ± 15.52
3 (6) 277 ± 19.13 298 ± 26.01 215 ± 17.93 194 ± 16.58 247 ± 11.99 274 ± 19.53
4 (5) 282 ± 30.50 290 ± 26.66 214 ± 15.00 193 ± 15.97 251 ± 15.56 278 ± 20.03
5 (6) 276 ± 18.01 290 ± 39.66 212 ± 15.61 193 ± 13.88 257 ± 30.82 282 ± 24.58*
6 (5) 271 ± 15.55 298 ± 42.95* 215 ± 13.24* 191 ± 9.46 272 ± 43.96* 279 ± 26.52*
BT (°C) 1 (6) 37.50 ± 0.21 37.18 ± 0.16 36.88 ± 0.25 36.09 ± 0.17 35.67 ± 0.20 37.17 ± 0.58
2 (6) 37.48 ± 0.34 37.44 ± 0.31 37.05 ± 0.34 36.11 ± 0.25 35.65 ± 0.17 37.14 ± 0.48
3 (6) 37.27 ± 0.29 37.17 ± 0.36 36.86 ± 0.25 36.07 ± 0.26 35.66 ± 0.36 37.14 ± 0.36
4 (5) 37.58 ± 0.31 37.50 ± 0.37 37.24 ± 0.36* 36.28 ± 0.24 35.78 ± 0.25 37.32 ± 0.26
5 (6) 37.46 ± 0.19 37.13 ± 0.39 36.94 ± 0.42 36.08 ± 0.36 35.63 ± 0.28 37.23 ± 0.31
6 (5) 37.28 ± 0.28 37.18 ± 0.15 36.90 ± 0.16 35.96 ± 0.35 35.53 ± 0.42 37.38 ± 0.29
  1. *Statistical significant difference (p value ≤ 0.05) based on the ANCOVA with baseline as covariate for the comparison of anaesthetic stages between run 2–6 versus run 1.