Parameter | Run | Baseline | Induction | Non-surgical tolerance | Surgical tolerance | Wake-up | Recovery |
---|---|---|---|---|---|---|---|
 | (No. of animals) | Mean ± SD | Mean ± SD | Mean ± SD | Mean ± SD | Mean ± SD | Mean ± SD |
SAP (mmHg) | 1 (6) | 117 ± 5.42 | 158 ± 19.28 | 160 ± 21.24 | 157 ± 23.24 | 101 ± 15.20 | 113 ± 9.43 |
2 (6) | 111 ± 7.34 | 144 ± 19.22* | 151 ± 24.77 | 151 ± 25.47 | 105 ± 15.15 | 113 ± 7.08 | |
3 (6) | 112 ± 9.32 | 153 ± 18.24 | 152 ± 23.21 | 147 ± 24.90* | 101 ± 13.70 | 115 ± 7.90 | |
4 (5) | 116 ± 8.18 | 149 ± 19.24 | 157 ± 28.86 | 146 ± 20.77 | 102 ± 11.90 | 114 ± 11.13 | |
5 (6) | 115 ± 6.49 | 153 ± 19.81 | 154 ± 21.44 | 146 ± 25.10* | 103 ± 10.03 | 117 ± 9.90 | |
6 (5) | 117 ± 11.54 | 150 ± 17.01 | 146 ± 14.86* | 148 ± 26.76 | 109 ± 17.16* | 121 ± 11.21* | |
DAP (mmHg) | 1 (6) | 89 ± 4.40 | 120 ± 15.38 | 112 ± 7.78 | 107 ± 12.31 | 76 ± 13.69 | 90 ± 11.00 |
2 (6) | 84 ± 7.51 | 112 ± 10.63 | 106 ± 12.00 | 103 ± 12.22 | 81 ± 10.84 | 90 ± 6.40 | |
3 (6) | 84 ± 5.49 | 117 ± 12.26 | 108 ± 9.00 | 103 ± 11.24 | 77 ± 11.00 | 91 ± 9.09 | |
4 (5) | 89 ± 13.66 | 114 ± 6.48 | 111 ± 15.30 | 101 ± 6.64 | 76 ± 4.93 | 91 ± 13.87 | |
5 (6) | 87 ± 5.85 | 116 ± 9.81 | 112 ± 8.85 | 103 ± 9.61 | 78 ± 8.78 | 92 ± 10.43 | |
6 (5) | 89 ± 12.07 | 117 ± 10.93 | 110 ± 7.56 | 106 ± 10.62 | 84 ± 12.95 | 97 ± 11.12* | |
MAP (mmHg) | 1 (6) | 98 ± 2.90 | 132 ± 15.27 | 128 ± 10.61 | 123 ± 14.23 | 84 ± 13.90 | 98 ± 10.09 |
2 (6) | 93 ± 6.90 | 123 ± 12.88* | 121 ± 15.41 | 119 ± 15.59 | 89 ± 12.11 | 98 ± 6.27 | |
3 (6) | 93 ± 5.91 | 129 ± 12.90 | 123 ± 12.68 | 118 ± 14.39 | 85 ± 11.55 | 99 ± 8.38 | |
4 (5) | 98 ± 11.61 | 126 ± 9.62 | 126 ± 19.01 | 116 ± 10.48 | 84 ± 6.59 | 99 ± 12.78 | |
5 (6) | 96 ± 5.27 | 128 ± 12.79 | 126 ± 12.53 | 117 ± 14.16 | 86 ± 8.81 | 101 ± 9.98 | |
6 (5) | 98 ± 11.39 | 128 ± 12.03 | 122 ± 8.47 | 120 ± 15.02 | 93 ± 14.07* | 105 ± 10.66* | |
PP (mmHg) | 1 (6) | 28 ± 8.01 | 38 ± 14.80 | 48 ± 18.77 | 51 ± 18.78 | 25 ± 6.32 | 23 ± 6.17 |
2 (6) | 27 ± 5.94 | 33 ± 12.11 | 45 ± 16.81 | 48 ± 18.10 | 24 ± 6.08 | 23 ± 4.64 | |
3 (6) | 28 ± 7.98 | 36 ± 14.18 | 43 ± 18.11 | 44 ± 19.42* | 24 ± 6.67 | 24 ± 5.03 | |
4 (5) | 27 ± 7.33 | 35 ± 16.25 | 46 ± 18.03 | 45 ± 16.88 | 27 ± 9.47 | 23 ± 5.29 | |
5 (6) | 28 ± 6.38 | 37 ± 11.88 | 42 ± 14.75* | 43 ± 17.89* | 25 ± 5.78 | 24 ± 5.08 | |
6 (5) | 28 ± 7.29 | 33 ± 11.90* | 36 ± 13.39* | 42 ± 19.92* | 25 ± 7.30 | 24 ± 6.96 | |
HR (bpm) | 1 (6) | 289 ± 23.42 | 285 ± 37.92 | 211 ± 16.99 | 197 ± 19.63 | 249 ± 19.49 | 275 ± 15.28 |
2 (6) | 274 ± 14.20 | 285 ± 45.73 | 214 ± 14.44 | 195 ± 15.42 | 255 ± 23.43 | 276 ± 15.52 | |
3 (6) | 277 ± 19.13 | 298 ± 26.01 | 215 ± 17.93 | 194 ± 16.58 | 247 ± 11.99 | 274 ± 19.53 | |
4 (5) | 282 ± 30.50 | 290 ± 26.66 | 214 ± 15.00 | 193 ± 15.97 | 251 ± 15.56 | 278 ± 20.03 | |
5 (6) | 276 ± 18.01 | 290 ± 39.66 | 212 ± 15.61 | 193 ± 13.88 | 257 ± 30.82 | 282 ± 24.58* | |
6 (5) | 271 ± 15.55 | 298 ± 42.95* | 215 ± 13.24* | 191 ± 9.46 | 272 ± 43.96* | 279 ± 26.52* | |
BT (°C) | 1 (6) | 37.50 ± 0.21 | 37.18 ± 0.16 | 36.88 ± 0.25 | 36.09 ± 0.17 | 35.67 ± 0.20 | 37.17 ± 0.58 |
2 (6) | 37.48 ± 0.34 | 37.44 ± 0.31 | 37.05 ± 0.34 | 36.11 ± 0.25 | 35.65 ± 0.17 | 37.14 ± 0.48 | |
3 (6) | 37.27 ± 0.29 | 37.17 ± 0.36 | 36.86 ± 0.25 | 36.07 ± 0.26 | 35.66 ± 0.36 | 37.14 ± 0.36 | |
4 (5) | 37.58 ± 0.31 | 37.50 ± 0.37 | 37.24 ± 0.36* | 36.28 ± 0.24 | 35.78 ± 0.25 | 37.32 ± 0.26 | |
5 (6) | 37.46 ± 0.19 | 37.13 ± 0.39 | 36.94 ± 0.42 | 36.08 ± 0.36 | 35.63 ± 0.28 | 37.23 ± 0.31 | |
6 (5) | 37.28 ± 0.28 | 37.18 ± 0.15 | 36.90 ± 0.16 | 35.96 ± 0.35 | 35.53 ± 0.42 | 37.38 ± 0.29 |