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Table 3 Medetomidine-midazolam-fentanyl – mean values with standard deviation

From: Influence of repeated anaesthesia on physiological parameters in male Wistar rats: a telemetric study about isoflurane, ketamine-xylazine and a combination of medetomidine, midazolam and fentanyl

Parameter

Run

Baseline

Induction

Non-surgical tolerance

Surgical tolerance

Wake-up

Recovery

 

(No. of animals)

Mean ± SD

Mean ± SD

Mean ± SD

Mean ± SD

Mean ± SD

Mean ± SD

SAP (mmHg)

1 (6)

117 ± 5.42

158 ± 19.28

160 ± 21.24

157 ± 23.24

101 ± 15.20

113 ± 9.43

2 (6)

111 ± 7.34

144 ± 19.22*

151 ± 24.77

151 ± 25.47

105 ± 15.15

113 ± 7.08

3 (6)

112 ± 9.32

153 ± 18.24

152 ± 23.21

147 ± 24.90*

101 ± 13.70

115 ± 7.90

4 (5)

116 ± 8.18

149 ± 19.24

157 ± 28.86

146 ± 20.77

102 ± 11.90

114 ± 11.13

5 (6)

115 ± 6.49

153 ± 19.81

154 ± 21.44

146 ± 25.10*

103 ± 10.03

117 ± 9.90

6 (5)

117 ± 11.54

150 ± 17.01

146 ± 14.86*

148 ± 26.76

109 ± 17.16*

121 ± 11.21*

DAP (mmHg)

1 (6)

89 ± 4.40

120 ± 15.38

112 ± 7.78

107 ± 12.31

76 ± 13.69

90 ± 11.00

2 (6)

84 ± 7.51

112 ± 10.63

106 ± 12.00

103 ± 12.22

81 ± 10.84

90 ± 6.40

3 (6)

84 ± 5.49

117 ± 12.26

108 ± 9.00

103 ± 11.24

77 ± 11.00

91 ± 9.09

4 (5)

89 ± 13.66

114 ± 6.48

111 ± 15.30

101 ± 6.64

76 ± 4.93

91 ± 13.87

5 (6)

87 ± 5.85

116 ± 9.81

112 ± 8.85

103 ± 9.61

78 ± 8.78

92 ± 10.43

6 (5)

89 ± 12.07

117 ± 10.93

110 ± 7.56

106 ± 10.62

84 ± 12.95

97 ± 11.12*

MAP (mmHg)

1 (6)

98 ± 2.90

132 ± 15.27

128 ± 10.61

123 ± 14.23

84 ± 13.90

98 ± 10.09

2 (6)

93 ± 6.90

123 ± 12.88*

121 ± 15.41

119 ± 15.59

89 ± 12.11

98 ± 6.27

3 (6)

93 ± 5.91

129 ± 12.90

123 ± 12.68

118 ± 14.39

85 ± 11.55

99 ± 8.38

4 (5)

98 ± 11.61

126 ± 9.62

126 ± 19.01

116 ± 10.48

84 ± 6.59

99 ± 12.78

5 (6)

96 ± 5.27

128 ± 12.79

126 ± 12.53

117 ± 14.16

86 ± 8.81

101 ± 9.98

6 (5)

98 ± 11.39

128 ± 12.03

122 ± 8.47

120 ± 15.02

93 ± 14.07*

105 ± 10.66*

PP (mmHg)

1 (6)

28 ± 8.01

38 ± 14.80

48 ± 18.77

51 ± 18.78

25 ± 6.32

23 ± 6.17

2 (6)

27 ± 5.94

33 ± 12.11

45 ± 16.81

48 ± 18.10

24 ± 6.08

23 ± 4.64

3 (6)

28 ± 7.98

36 ± 14.18

43 ± 18.11

44 ± 19.42*

24 ± 6.67

24 ± 5.03

4 (5)

27 ± 7.33

35 ± 16.25

46 ± 18.03

45 ± 16.88

27 ± 9.47

23 ± 5.29

5 (6)

28 ± 6.38

37 ± 11.88

42 ± 14.75*

43 ± 17.89*

25 ± 5.78

24 ± 5.08

6 (5)

28 ± 7.29

33 ± 11.90*

36 ± 13.39*

42 ± 19.92*

25 ± 7.30

24 ± 6.96

HR (bpm)

1 (6)

289 ± 23.42

285 ± 37.92

211 ± 16.99

197 ± 19.63

249 ± 19.49

275 ± 15.28

2 (6)

274 ± 14.20

285 ± 45.73

214 ± 14.44

195 ± 15.42

255 ± 23.43

276 ± 15.52

3 (6)

277 ± 19.13

298 ± 26.01

215 ± 17.93

194 ± 16.58

247 ± 11.99

274 ± 19.53

4 (5)

282 ± 30.50

290 ± 26.66

214 ± 15.00

193 ± 15.97

251 ± 15.56

278 ± 20.03

5 (6)

276 ± 18.01

290 ± 39.66

212 ± 15.61

193 ± 13.88

257 ± 30.82

282 ± 24.58*

6 (5)

271 ± 15.55

298 ± 42.95*

215 ± 13.24*

191 ± 9.46

272 ± 43.96*

279 ± 26.52*

BT (°C)

1 (6)

37.50 ± 0.21

37.18 ± 0.16

36.88 ± 0.25

36.09 ± 0.17

35.67 ± 0.20

37.17 ± 0.58

2 (6)

37.48 ± 0.34

37.44 ± 0.31

37.05 ± 0.34

36.11 ± 0.25

35.65 ± 0.17

37.14 ± 0.48

3 (6)

37.27 ± 0.29

37.17 ± 0.36

36.86 ± 0.25

36.07 ± 0.26

35.66 ± 0.36

37.14 ± 0.36

4 (5)

37.58 ± 0.31

37.50 ± 0.37

37.24 ± 0.36*

36.28 ± 0.24

35.78 ± 0.25

37.32 ± 0.26

5 (6)

37.46 ± 0.19

37.13 ± 0.39

36.94 ± 0.42

36.08 ± 0.36

35.63 ± 0.28

37.23 ± 0.31

6 (5)

37.28 ± 0.28

37.18 ± 0.15

36.90 ± 0.16

35.96 ± 0.35

35.53 ± 0.42

37.38 ± 0.29

  1. *Statistical significant difference (p value ≤ 0.05) based on the ANCOVA with baseline as covariate for the comparison of anaesthetic stages between run 2–6 versus run 1.