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Table 2 Ketamine-Xylazine– mean values with standard deviation

From: Influence of repeated anaesthesia on physiological parameters in male Wistar rats: a telemetric study about isoflurane, ketamine-xylazine and a combination of medetomidine, midazolam and fentanyl

Parameter Run Baseline Induction Non-surgical tolerance Recovery
  (No. of animals) Mean ± SD Mean ± SD Mean ± SD Mean ± SD
SAP (mmHg) 1 (6) 116 ± 11.27 130 ± 12.81 96 ± 12.38 104 ± 9.16
2 (6) 118 ± 11.85 133 ± 13.38 97 ± 7.07 106 ± 8.86
3 (6) 114 ± 7.93 134 ± 11.38 96 ± 10.78 106 ± 6.18
4 (6) 116 ± 10.03 138 ± 10.86* 95 ± 9.36 105 ± 6.09
5 (6) 115 ± 9.65 133 ± 6.83 100 ± 9.89 103 ± 5.40
6 (5) 115 ± 6.14 138 ± 6.62 102 ± 6.18 105 ± 4.85
DAP (mmHg) 1 (6) 85 ± 9.85 96 ± 9.39 68 ± 10.01 76 ± 6.38
2 (6) 88 ± 10.40 96 ± 13.27 69 ± 7.57 77 ± 8.68
3 (6) 86 ± 10.10 103 ± 7.13 69 ± 9.81 78 ± 6.66
4 (6) 87 ± 8.15 103 ± 8.76 69 ± 7.13 75 ± 2.87
5 (6) 86 ± 7.04 99 ± 7.09 72 ± 9.14 75 ± 2.57
6 (5) 84 ± 5.83 102 ± 6.44 71 ± 5.24* 74 ± 1.39
MAP (mmHg) 1 (6) 95 ± 10.13 108 ± 10.35 77 ± 10.65 85 ± 7.08
2 (6) 98 ± 10.40 108 ± 12.93 79 ± 6.68 87 ± 8.34
3 (6) 95 ± 8.86 113 ± 8.12 78 ± 9.29 87 ± 5.76
4 (6) 96 ± 8.40 115 ± 9.05 78 ± 6.92 85 ± 3.64
5 (6) 96 ± 7.24 110 ± 6.16 81 ± 8.42 84 ± 2.20
6 (5) 95 ± 5.50 114 ± 6.35 81 ± 5.07 85 ± 2.39
PP (mmHg) 1 (6) 31 ± 4.42 34 ± 5.40 28 ± 4.52 28 ± 4.74
2 (6) 30 ± 6.95 36 ± 6.67* 28 ± 6.76 29 ± 5.51
3 (6) 28 ± 6.89 32 ± 7.08 27 ± 8.65 27 ± 6.39
4 (6) 30 ± 5.73 35 ± 6.20* 27 ± 8.29 30 ± 4.57*
5 (6) 29 ± 7.22 33 ± 7.09 28 ± 8.86 28 ± 6.47
6 (5) 31 ± 4.71 36 ± 2.97 31 ± 4.91 31 ± 3.94*
HR (bpm) 1 (6) 283 ± 36.14 354 ± 38.00 273 ± 23.56 288 ± 19.35
2 (6) 284 ± 20.10 375 ± 45.16 281 ± 20.12 292 ± 12.37
3 (6) 278 ± 14.31 359 ± 33.95 273 ± 19.86 296 ± 21.69
4 (6) 281 ± 22.22 340 ± 28.56 275 ± 35.47 290 ± 27.95
5 (6) 285 ± 20.98 362 ± 31.88 275 ± 29.33 292 ± 13.50
6 (5) 282 ± 21.89 362 ± 10.24 269 ± 21.50 277 ± 18.54
BT (°C) 1 (6) 37.39 ± 0.59 37.34 ± 0.63 36.96 ± 0.48 37.57 ± 0.47
2 (6) 37.49 ± 0.27 37.44 ± 0.22 37.34 ± 0.32* 37.79 ± 0.32
3 (6) 37.42 ± 0.19 37.27 ± 0.24 37.18 ± 0.37 37.72 ± 0.31
4 (6) 37.59 ± 0.23 37.40 ± 0.26 37.35 ± 0.45* 37.54 ± 0.53
5 (6) 37.56 ± 0.37 37.55 ± 0.39 37.46 ± 0.45* 37.79 ± 0.32
6 (5) 37.73 ± 0.48 37.58 ± 0.58 37.43 ± 0.36* 37.79 ± 0.08
  1. *Statistical significant difference (p value ≤ 0.05) based on the ANCOVA with baseline as covariate for the comparison of anaesthetic stages between run 2–6 versus run 1.