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Table 5 SOD, GPx, PGE 2 and lipid peroxidation(MDA) properties of HPTP in indomethacin-induced gastric lesions in rats

From: Protective effects of (1-(4-hydroxy-phenyl)-3-m-tolyl-propenone chalcone in indomethacin-induced gastric erosive damage in rats

Pre-treatment (5 ml/kg) GPX (μmol/mg) SOD (μmol/mg) PGE2 (U/ml) MDA (nmol/ml)
Normal (0.5% CMC) 33.72 ± 1.80*a 130.06 ± 11.58*a 681.03 ± 37.83*a 4.12 ± 0.37*a
Indomethacin 100 mg/kg 20.02 ± 0.97 67.55 ± 4.63 163.07 ± 11.68 8.78 ± 0.78
HPTP 50 mg/kg 22.33 ± 1.47 112.78 ± 3.31* 410.52 ± 16.38* 4.6 ± 0.67*
HPTP 100 mg/kg 25.22 ± 1.93 128.42 ± 7.98* 419.85 ± 28.92* 2.25 ± 0. 59*
Omeprazole 20 mg/kg 33.23 ± 1.11* 125.16 ± 1.53* 653.77 ± 19.99* 1.79 ± 0.19*
  1. Values are expressed as Mean ± SEM. (*a) indicates significance at P < 0.05 versus normal control with indomethacin group, (*) P < 0.05 versus indomethacin with all treated groups. GPx = Glutathione peroxidase, SOD = Superoxide dismutase, PGE2 = Prostaglandin E2, MDA = Estimation of lipid peroxidation level.