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Table 5 SOD, GPx, PGE 2 and lipid peroxidation(MDA) properties of HPTP in indomethacin-induced gastric lesions in rats

From: Protective effects of (1-(4-hydroxy-phenyl)-3-m-tolyl-propenone chalcone in indomethacin-induced gastric erosive damage in rats

Pre-treatment (5 ml/kg)

GPX (μmol/mg)

SOD (μmol/mg)

PGE2 (U/ml)

MDA (nmol/ml)

Normal (0.5% CMC)

33.72 ± 1.80*a

130.06 ± 11.58*a

681.03 ± 37.83*a

4.12 ± 0.37*a

Indomethacin 100 mg/kg

20.02 ± 0.97

67.55 ± 4.63

163.07 ± 11.68

8.78 ± 0.78

HPTP 50 mg/kg

22.33 ± 1.47

112.78 ± 3.31*

410.52 ± 16.38*

4.6 ± 0.67*

HPTP 100 mg/kg

25.22 ± 1.93

128.42 ± 7.98*

419.85 ± 28.92*

2.25 ± 0. 59*

Omeprazole 20 mg/kg

33.23 ± 1.11*

125.16 ± 1.53*

653.77 ± 19.99*

1.79 ± 0.19*

  1. Values are expressed as Mean ± SEM. (*a) indicates significance at P < 0.05 versus normal control with indomethacin group, (*) P < 0.05 versus indomethacin with all treated groups. GPx = Glutathione peroxidase, SOD = Superoxide dismutase, PGE2 = Prostaglandin E2, MDA = Estimation of lipid peroxidation level.
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BMC Veterinary Research

ISSN: 1746-6148

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