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Table 4 Effects of HPTP on gastric ulcer induced by indomethacin in rats

From: Protective effects of (1-(4-hydroxy-phenyl)-3-m-tolyl-propenone chalcone in indomethacin-induced gastric erosive damage in rats

Pre-treatment (5 ml/kg) Gastric pH Mucus barrier μg/g tissue Ulcer area (mm 2) % inhibition
Normal (0.5% CMC) 6.36 ± 0.24* 27.67 ± 1.97* ---- ----
Indomethacin 100 mg/kg 2.17 ± 0.07 7.17 ± 0.21 112.32 ± 11.74 ----
HPTP 50 mg/kg 3.10 ± 0.18* 21.97 ± 1.32* 38.88 ± 2.88* 65.4
HPTP 100 mg/kg 4.52 ± 0.17* 27.48 ± 1.08* 28.80 ± 2.28* 74.4
Omeprazole 20 mg/kg 5.7 ± 0.30* 28.43 ± 1.45* 10.08 ± 1.76* 91.04
  1. Values are expressed as Mean ± SEM. (*) indicates significant at P < 0.05 versus indomethacin (ulcerated) group with pre-treatment groups.