Skip to main content

Table 4 Effects of HPTP on gastric ulcer induced by indomethacin in rats

From: Protective effects of (1-(4-hydroxy-phenyl)-3-m-tolyl-propenone chalcone in indomethacin-induced gastric erosive damage in rats

Pre-treatment (5 ml/kg)

Gastric pH

Mucus barrier μg/g tissue

Ulcer area (mm 2)

% inhibition

Normal (0.5% CMC)

6.36 ± 0.24*

27.67 ± 1.97*

----

----

Indomethacin 100 mg/kg

2.17 ± 0.07

7.17 ± 0.21

112.32 ± 11.74

----

HPTP 50 mg/kg

3.10 ± 0.18*

21.97 ± 1.32*

38.88 ± 2.88*

65.4

HPTP 100 mg/kg

4.52 ± 0.17*

27.48 ± 1.08*

28.80 ± 2.28*

74.4

Omeprazole 20 mg/kg

5.7 ± 0.30*

28.43 ± 1.45*

10.08 ± 1.76*

91.04

  1. Values are expressed as Mean ± SEM. (*) indicates significant at P < 0.05 versus indomethacin (ulcerated) group with pre-treatment groups.