Table 1 Effects of HPTP on renal function test (male and female rats) in acute toxicity studies
Male | Sodium mmol/L | Potassium mmol/L | Chloride mmol/L | CO 2mmol/L | An.gap mmol/L | Urea mmol/L | Creatinine μmol/L |
|---|---|---|---|---|---|---|---|
CMC 0.5% | 147.8 ± 0.5 | 4.9 ± 0.2 | 112.8 ± 0.8 | 15.5 ± 0.78 | 24 ± 0.4 | 8.3 ± 0.6 | 31.5 ± 1.6 |
250 mg/kg | 148.5 ± 2.2 | 4.8 ± 0.2 | 109.5 ± 2.8 | 15.6 ± 1.3 | 24.8 ± 0.9 | 6.2 ± 0.8 | 29.3 ± 1.6 |
500 mg/kg | 149.5 ± 3.2 | 4.9 ± 0.4 | 111.5 ± 2.0 | 14.1 ± 0.5 | 24.8 ± 1.0 | 8.2 ± 1.3 | 30.0 ± 0.7 |
1000 g/kg | 151.0 ± 2.4 | 5.2 ± 0.3 | 115.8 ± 1.7 | 13.8 ± 0.4 | 27 ± 1.9 | 11.3 ± 1.1 | 35.3 ± 2.3 |
Female | |||||||
CMC 0.5% | 147.8 ± 0.6 | 4.9 ± 0.1 | 112.3 ± 1.7 | 13.4 ± 0.9 | 26.8 ± 0.5 | 7.2 ± 0.4 | 29.3 ± 1.3 |
250 mg/kg | 147.8 ± 3.1 | 4.9 ± 0.1 | 109.3 ± 3.5 | 16.7 ± 1.2 | 27.3 ± 1.7 | 6.7 ± 1.1 | 30.0 ± 1.2 |
500 mg/kg | 147.3 ± 1.6 | 5.3 ± 0.4 | 115.3 ± 3.7 | 14.3 ± 0.4 | 29.3 ± 1.0 | 7.8 ± 1.1 | 25.5 ± 2.0 |
1000 mg/kg | 152.3 ± 1.7 | 5.4 ± 0.3 | 120.0 ± 2.5 | 14.0 ± 0.8 | 28.3 ± 3.0 | 6.6 ± 1.2 | 28.5 ± 2.3 |