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Table 2 Correlation of pharmacokinetic/pharmacodynamics (PK/PD) parameters with selection of resistance

From: In vivo evaluation of mutant selection window of cefquinome against Escherichia coliin piglet tissue-cage model

PK/PD index, value a Fraction of tissue-cages with resistant bacteria (mutant/total) P b
T > MIC99   
≤25% 1/10 0.625
>25% 17/24 0.003
T > MPC   
<50% 17/26 0.006
≥50% 1/8 0.400
AUC24 h/MIC99 (h)   
≤32.84 1/8 0.571
32.84-125.64 16/20 0.001
≥125.64 1/6 0.500
AUC24 h/MPC (h)   
≤12.83 1/8 0.571
12.83-49.09 16/20 0.001
>49.09 1/6 0.500
Cmax/MIC99   
≤1.32 1/9 0.600
1.32-4.26 16/18 0.0002
≥4.26 1/7 0.539
Cmax/MPC   
≤0.52 1/9 0.600
0.52-1.66 16/18 0.0002
≥1.66 1/7 0.539
  1. All PK/PD parameters were determined using total drug concentrations in tissue cage fluid. Total 34 tissue cages were analyzed and 2 tissue cages excluded because of bacterial pollution.
  2. aTine in the window (Tmsw) is not presented in the table because it fell into 2 categories.
  3. bP values were calculated by Fishers exact test, with a set of 3 infected but untreated piglets (6 tissue-cages) used as a control. High values indicate no difference with the control.