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Table 1 Values of PK/PD parameters and change of MIC in different cefquinome concentrations (18 piglets, 7 groups, treated at 0.1, 0.2, 0.4, 0.8, or 1.0 mg/kg of body weight once a day or 0.2 and 0.4 mg/kg of body weight twice a day)

From: In vivo evaluation of mutant selection window of cefquinome against Escherichia coliin piglet tissue-cage model

Groups

PK/PD parameters

Interval (h)

MIC (μg/mL)

A1 (N = 2)

T > MIC99% = 0

24

Total 4 cages, no increase

A2 (N = 2)

T > MPC% = 100%

24

Total 3 cages, no increase

A3 (N = 3)

T > MIC99% = 25%

24

1/total 6 cages, increased to 0.512

T > MPC% = 0

TMSW% = 25%

A4 (N = 3)

T > MIC99% = 100%

24

1/total 5 cages, increased to 0.512

T > MPC% = 50%

TMSW% = 50%

A5 (N = 2) & A6 (N = 3)

T > MIC99% = 100%

24

8/total 8 cages, increased to 2.048

T > MPC% ≤ 25%

75% ≤ TMSW% ≤ 100%

A7 (N = 3) & A8 (N = 2)

T > MIC99% = 100%

12

8/total 8cages, increased to 0.512

T > MPC% = 0

TMSW% = 100%

  1. Cefquinome PK/PD values were determined from tissue cage fluids using total drug concentrations. N is the animal number per group.