Groups | PK/PD parameters | Interval (h) | MIC (μg/mL) |
---|---|---|---|
A1 (N = 2) | T > MIC99% = 0 | 24 | Total 4 cages, no increase |
A2 (N = 2) | T > MPC% = 100% | 24 | Total 3 cages, no increase |
A3 (N = 3) | T > MIC99% = 25% | 24 | 1/total 6 cages, increased to 0.512 |
T > MPC% = 0 | |||
TMSW% = 25% | |||
A4 (N = 3) | T > MIC99% = 100% | 24 | 1/total 5 cages, increased to 0.512 |
T > MPC% = 50% | |||
TMSW% = 50% | |||
A5 (N = 2) & A6 (N = 3) | T > MIC99% = 100% | 24 | 8/total 8 cages, increased to 2.048 |
T > MPC% ≤ 25% | |||
75% ≤ TMSW% ≤ 100% | |||
A7 (N = 3) & A8 (N = 2) | T > MIC99% = 100% | 12 | 8/total 8cages, increased to 0.512 |
T > MPC% = 0 | |||
TMSW% = 100% |