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Table 1 Values of PK/PD parameters and change of MIC in different cefquinome concentrations (18 piglets, 7 groups, treated at 0.1, 0.2, 0.4, 0.8, or 1.0 mg/kg of body weight once a day or 0.2 and 0.4 mg/kg of body weight twice a day)

From: In vivo evaluation of mutant selection window of cefquinome against Escherichia coliin piglet tissue-cage model

Groups PK/PD parameters Interval (h) MIC (μg/mL)
A1 (N = 2) T > MIC99% = 0 24 Total 4 cages, no increase
A2 (N = 2) T > MPC% = 100% 24 Total 3 cages, no increase
A3 (N = 3) T > MIC99% = 25% 24 1/total 6 cages, increased to 0.512
T > MPC% = 0
TMSW% = 25%
A4 (N = 3) T > MIC99% = 100% 24 1/total 5 cages, increased to 0.512
T > MPC% = 50%
TMSW% = 50%
A5 (N = 2) & A6 (N = 3) T > MIC99% = 100% 24 8/total 8 cages, increased to 2.048
T > MPC% ≤ 25%
75% ≤ TMSW% ≤ 100%
A7 (N = 3) & A8 (N = 2) T > MIC99% = 100% 12 8/total 8cages, increased to 0.512
T > MPC% = 0
TMSW% = 100%
  1. Cefquinome PK/PD values were determined from tissue cage fluids using total drug concentrations. N is the animal number per group.