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Table 2 Variably expressed mapped genes in the uterine tissues of ewes in different groups

From: Insights into potential pathogenesis mechanisms associated with Campylobacter jejuni-induced abortion in ewes

Gene description a

Fold change

C-vs-G1

C-vs-G2

C-vs-G3

G1-vs-G2

G1-vs-G3

G2-vs-G3

ASRGL1, Asparaginase like 1

3.14

2.09

    

ATF4, Activating transcription factor 4 (tax-responsive enhancer element B67)

3.19

2.10

    

BRS3, Bombesin-like receptor 3

3.07

2.38

    

CAPN1, Calpain 1, (mu/I) large subunit

  

2.78

2.52

  

CD28, CD28 molecule

 

-2.64

    

CDKN2AIPNL, CDKN2A interacting protein N-terminal like

  

-3.15

   

CHRD, Chordin

 

-1.90

-2.35

-2.32

-2.33

 

CLN5, Ceroid-lipofuscinosis, neuronal 5

4.20

  

-2.17

  

CYB561, Cytochrome b-561

-4.82

 

-4.81

2.80

  

DOHH, Deoxyhypusine hydroxylase/monooxygenase

-5.27

  

3.64

5.85

 

EEF1A1, Eukaryotic translation elongation factor 1 alpha 1

-7.51

  

7.17

  

EGR1, Early growth response 1

    

2.10

2.00

EPAS1, Endothelial PAS domain protein 1

-5.61

-1.92

 

4.41

5.80

2.33

FGF7, Fibroblast growth factor 7

3.44

2.06

2.00

   

FGFR2, Fibroblast growth factor receptor 2

   

-2.30

  

GATA6, GATA binding protein 6

 

-1.91

-2.00

   

GGCX, Gamma-glutamyl carboxylase

  

2.02

2.39

3.49

2.00

GNLY, Granulysin

 

2.31

    

GNRH1, Gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)

 

-2.18

    

GRIA1, Glutamate receptor, ionotropic, AMPA 1

  

2.27

   

HSPA5, Heat shock 70 kDa protein 5 (glucose-regulated protein, 78 kDa)

   

-2.09

  

IFNAR2, Interferon (alpha, beta and omega) receptor 2

   

2.30

  

IL5, Interleukin 5 (colony-stimulating factor, eosinophil)

 

2.47

    

IL6, Interleukin 6 (interferon, beta 2)

  

2.02

 

1.95

2.21

IL12B, Interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)

3.06

2.14

    

IL15, Interleukin 15

1.90

-2.06

  

3.60

2.00

INSL3, Insulin-like 3 (Leydig cell)

 

-2.06

-3.19

   

ITGAL, Integrin, alpha L (antigen CD11A (p180), lymphocyte function- associated antigen 1; alpha polypeptide)

 

-1.99

-3.54

   

ITGB2, Integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)

 

-1.90

    

MC1R, Melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)

-3.89

-2.82

  

3.19

2.32

MMP2, Matrix metallopeptidase 2 (gelatinase A, 72 kDa gelatinase, 72 kDa type IV collagenase)

   

2.10

2.40

 

MMP9, Matrix metallopeptidase 9 (gelatinase B, 92 kDa gelatinase, 92 kDa type IV collagenase)

   

2.00

  

MMP13, Matrix metallopeptidase 13 (collagenase 3)

  

2.00

   

MYC, V-myc myelocytomatosis viral oncogene homolog

5.64

2.11

 

-2.66

  

PCK1, Phosphoenolpyruvate carboxykinase 1 (soluble)

 

2.82

    

PCNA, Proliferating cell nuclear antigen

-3.48

  

2.30

4.85

2.10

PGD, Phosphogluconate dehydrogenase

3.54

2.00

    

PLIN5, Perilipin 5

     

2.04

PRL, Prolactin

-3.52

  

3.05

4.29

 

PTGER3, Prostaglandin E receptor 3 (subtype EP3)

  

-2.39

   

PTGER4, Prostaglandin E receptor 4 (subtype EP4)

  

-1.90

 

-2.00

-2.00

SLC4A4, Solute carrier family 4, sodium bicarbonate cotransporter, member 4

-3.55

 

-3.00

2.39

  

SLC11A1, Solute carrier family 11

  

-2.36

   

SLC25A5, Solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5

-4.06

   

3.15

 

SCNN1A, Sodium channel, non-voltage-gated 1 alpha subunit

    

2.89

2.09

SLPI, Secretory leukocyte peptidase inhibitor

   

2.45

3.71

 

ST3GAL4, ST3 beta-galactoside alpha-2,3-sialyltransferase 4

3.70

  

-2.58

  

TFF3, Trefoil factor 3 (intestinal)

   

-2.21

  

TRAF3, TNF receptor-associated factor 3

   

1.94

2.00

 

UGT1A9, UDP Glucuronosyltransferase 1 family, polypeptide A9

  

-5.24

2.49

  

ZGPAT, Zinc finger, CCCH-type with G patch domain

2.99

     
  1. aGene description is based on the Ingenuity Pathway Analysis (IPA) database. C, Control; G1, infected with 81-176; G2, infected with Bovine abortion isolate; G3, infected with Ovine abortion-II isolate. + Upregualted; - Downregulated.