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Table 2 Cadherin expression profiles and clinicopathological parameters of malignant tumours

From: Aberrant P-cadherin expression is associated to aggressive feline mammary carcinomas

Clinicopathological parameters n P-cadherin E-cadherin P-cadherin/E-cadherin
   Negative Positive Preserved Reduced +/+ +/− −/+ −/−
Histological type
 Tubulopapillary carcinoma 32 8 24 16 16 11 13 5 3
 Solid carcinoma 16 3 13 9 7 6 7 3 0
 Cribriforme carcinoma 4 1 3 4 0 3 0 1 0
 Mucinous carcinoma 6 0 6 1 5 1 5 0 0
 Carcinosarcoma 2 0 2 2 0 2 0 0 0
p   NS 0.0243 NS
Histological grade*
 Grade I 7 7 0 5 2 0 0 5 2
 Grade II 25 2 23 12 13 10 13 2 0
 Grade III 28 3 25 12 13 13 12 2 1
p   <0.0001 NS <0.0001
Mode of growth**
 Expansive 3 3 0 3 0 0 0 3 0
 Infiltrative 56 6 48 28 28 23 25 5 3
p   0.0051 NS 0.0044
Tumour largest diameter
 <2 cm 33 7 26 19 14 13 13 6 1
 2–3 cm 10 2 8 7 3 5 3 2 0
 >3 cm 17 3 14 6 11 5 9 1 2
p   NS NS NS
Ulceration          
 Absent 48 10 38 27 21 19 19 8 2
 Present 12 2 10 5 7 4 6 1 1
p   NS NS NS
Necrosis
 Absent 12 7 5 9 3 4 1 5 2
 Present 48 5 43 23 25 19 24 4 1
p   0.0010 NS 0.0026
Neoplastic intravascular emboli
 Absent 37 11 26 19 18 11 15 8 3
 Present 21 1 20 12 9 11 9 1 0
p   0.0401 NS NS
Odds ratio   8.4615 (1.0071-71.0959)  
Lymph node metastases
 Absent 17 3 14 10 7 7 7 3 0
 Present 18 0 18 10 8 10 8 0 0
p   NS NS NS
  1. NS -not significant.
  2. *According to Elston & Ellis 1998 [51].
  3. **In one case the margins were not included in sample.