Aberrant P-cadherin expression is associated to aggressive feline mammary carcinomas

BMC Veterinary Research

Table 2 Cadherin expression profiles and clinicopathological parameters of malignant tumours

Clinicopathological parameters	n	P-cadherin		E-cadherin		P-cadherin/E-cadherin
		Negative	Positive	Preserved	Reduced	+/+	+/−	−/+	−/−
Histological type
Tubulopapillary carcinoma	32	8	24	16	16	11	13	5	3
Solid carcinoma	16	3	13	9	7	6	7	3	0
Cribriforme carcinoma	4	1	3	4	0	3	0	1	0
Mucinous carcinoma	6	0	6	1	5	1	5	0	0
Carcinosarcoma	2	0	2	2	0	2	0	0	0
p		NS		0.0243		NS
Histological grade*
Grade I	7	7	0	5	2	0	0	5	2
Grade II	25	2	23	12	13	10	13	2	0
Grade III	28	3	25	12	13	13	12	2	1
p		<0.0001		NS		<0.0001
Mode of growth**
Expansive	3	3	0	3	0	0	0	3	0
Infiltrative	56	6	48	28	28	23	25	5	3
p		0.0051		NS		0.0044
Tumour largest diameter
<2 cm	33	7	26	19	14	13	13	6	1
2–3 cm	10	2	8	7	3	5	3	2	0
>3 cm	17	3	14	6	11	5	9	1	2
p		NS		NS		NS
Ulceration
Absent	48	10	38	27	21	19	19	8	2
Present	12	2	10	5	7	4	6	1	1
p		NS		NS		NS
Necrosis
Absent	12	7	5	9	3	4	1	5	2
Present	48	5	43	23	25	19	24	4	1
p		0.0010		NS		0.0026
Neoplastic intravascular emboli
Absent	37	11	26	19	18	11	15	8	3
Present	21	1	20	12	9	11	9	1	0
p		0.0401		NS		NS
Odds ratio		8.4615 (1.0071-71.0959)
Lymph node metastases
Absent	17	3	14	10	7	7	7	3	0
Present	18	0	18	10	8	10	8	0	0
p		NS		NS		NS

ISSN: 1746-6148