Table 2 Cadherin expression profiles and clinicopathological parameters of malignant tumours
From: Aberrant P-cadherin expression is associated to aggressive feline mammary carcinomas
| Clinicopathological parameters | n | P-cadherin | E-cadherin | P-cadherin/E-cadherin | |||||
|---|---|---|---|---|---|---|---|---|---|
| Negative | Positive | Preserved | Reduced | +/+ | +/− | −/+ | −/− | ||
| Histological type | |||||||||
| Tubulopapillary carcinoma | 32 | 8 | 24 | 16 | 16 | 11 | 13 | 5 | 3 |
| Solid carcinoma | 16 | 3 | 13 | 9 | 7 | 6 | 7 | 3 | 0 |
| Cribriforme carcinoma | 4 | 1 | 3 | 4 | 0 | 3 | 0 | 1 | 0 |
| Mucinous carcinoma | 6 | 0 | 6 | 1 | 5 | 1 | 5 | 0 | 0 |
| Carcinosarcoma | 2 | 0 | 2 | 2 | 0 | 2 | 0 | 0 | 0 |
| p | NS | 0.0243 | NS | ||||||
| Histological grade* | |||||||||
| Grade I | 7 | 7 | 0 | 5 | 2 | 0 | 0 | 5 | 2 |
| Grade II | 25 | 2 | 23 | 12 | 13 | 10 | 13 | 2 | 0 |
| Grade III | 28 | 3 | 25 | 12 | 13 | 13 | 12 | 2 | 1 |
| p | <0.0001 | NS | <0.0001 | ||||||
| Mode of growth** | |||||||||
| Expansive | 3 | 3 | 0 | 3 | 0 | 0 | 0 | 3 | 0 |
| Infiltrative | 56 | 6 | 48 | 28 | 28 | 23 | 25 | 5 | 3 |
| p | 0.0051 | NS | 0.0044 | ||||||
| Tumour largest diameter | |||||||||
| <2 cm | 33 | 7 | 26 | 19 | 14 | 13 | 13 | 6 | 1 |
| 2–3 cm | 10 | 2 | 8 | 7 | 3 | 5 | 3 | 2 | 0 |
| >3 cm | 17 | 3 | 14 | 6 | 11 | 5 | 9 | 1 | 2 |
| p | NS | NS | NS | ||||||
| Ulceration | |||||||||
| Absent | 48 | 10 | 38 | 27 | 21 | 19 | 19 | 8 | 2 |
| Present | 12 | 2 | 10 | 5 | 7 | 4 | 6 | 1 | 1 |
| p | NS | NS | NS | ||||||
| Necrosis | |||||||||
| Absent | 12 | 7 | 5 | 9 | 3 | 4 | 1 | 5 | 2 |
| Present | 48 | 5 | 43 | 23 | 25 | 19 | 24 | 4 | 1 |
| p | 0.0010 | NS | 0.0026 | ||||||
| Neoplastic intravascular emboli | |||||||||
| Absent | 37 | 11 | 26 | 19 | 18 | 11 | 15 | 8 | 3 |
| Present | 21 | 1 | 20 | 12 | 9 | 11 | 9 | 1 | 0 |
| p | 0.0401 | NS | NS | ||||||
| Odds ratio | 8.4615 (1.0071-71.0959) | ||||||||
| Lymph node metastases | |||||||||
| Absent | 17 | 3 | 14 | 10 | 7 | 7 | 7 | 3 | 0 |
| Present | 18 | 0 | 18 | 10 | 8 | 10 | 8 | 0 | 0 |
| p | NS | NS | NS | ||||||