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Table 5 Carprofen concentration measurements of plasma samples Group 6 (CA)

From: Preliminary study on carprofen concentration measurements after transcutaneous treatment with Vetdrop® in a microfracture joint defect model in sheep

Timepoint 5202 (CA) c(ng/ml) 5217 (CA) c(ng/ml)
Day 1 (day of surgery) 0.0 0.0
10 min. after 1st injection (day 1) 37500 39950
1 h after 1st injection (day 1) 29400 34217
2 h after 1st injection (day 1) 24400 27300
3 h after 1st injection (day 1) 23000 25917
12 h after 1st injection (day 1) 18200 23317
5 min prior to 2nd injection (day 2) 14100 21965
10 min after 2nd injection (day 2) 39100 43583
1 h after 2nd injection (day 2) 16000 38217
2 h after 2nd injection (day 2) 31400 37068
3 h after 2nd injection (day 2) 29200 35967
12 h after 2nd injection (day 2) 25900 31900
5 min prior to 3rd injection (day 3) 20000 25550
10 min after 3rd injection (day 3) 39700 42083
1 h after 3rd injection (day 3) 36100 40150
2 h after 3rd injection (day 3) 31900 36400
3 h after 3rd injection (day 3) 30100 34317
12 h after 3rd injection (day 3) 26200 31650
5 min prior to 4th injection (day 4)   27417
10 min after 4th injection (day 4)   41300
1 h after 4th injection (day 4)   39267
2 h after 4th injection (day 4)   37433
3 h after 4th injection (day 4)   36917
12 h after 4th injection (day 4)   32950
1 day after the last injection (day 5) 16200 23150
3 days after the last injection (day 8) 5200 6917
1 week after the last injection (day 12) 500 2115