Table 3 Carprofen concentrations of plasma samples Group 4 (VECHCA)
Timepoint | 5211 (VECHCA) c(ng/ml) | 5212 (VECHCA) c(ng/ml) |
|---|---|---|
Day 0 (1 day prior surgery) | 33.1 | 17.4 |
15 min. after 1st application (day 0) | 33.0 | 18.0 |
20 min. after 1st application (day 0) | 69.2 | 16.6 |
30 min. after 1st application (day 0) | 35.7 | 12.1 |
1 h after 1st application (day 0) | 40.5 | 13.7 |
2 h after 1st application (day 0) | 76.4 | 14.9 |
3 h after 1st application (day 0) | 120 | 20.0 |
6 h after 1st application (day 0) | 178 | 28.4 |
18 h after 1st application (day 1) | 342 | 81.9 |
Intra OP (day 1) | 297 | 88.7 |
5 min. prior to 2nd application (day 3) | 145 | 59.6 |
15 min. after 2nd application (day 3) | 114 | 52.3 |
20 min. after 2nd application (day 3) | 108 | 53.1 |
30 min. after 2nd application (day 3) | 134 | 57.8 |
1 h after 2nd application (day 3) | 135 | 58.9 |
2 h after 2nd application (day 3) | 188 | 65.4 |
3 h after 2nd application (day 3) | 269 | 85.8 |
6 h after 2nd application (day 3) | 360 | 176 |
18 h after 2nd application (day 4) | 572 | 353 |
6 h after application (week 1) | 849 | 448 |
6 h after application (week 2) | 882 | 365 |
6 h after application (week 3) | 959 | 490 |
6 h after application (week 4) | 949 | 525 |
6 h after application (week 5) | 1327 | 580 |
6 h after application (week 6) | 1347 | 391 |
1 week after the last application (week 7) | 486 | 146 |