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Table 3 Carprofen concentrations of plasma samples Group 4 (VECHCA)

From: Preliminary study on carprofen concentration measurements after transcutaneous treatment with Vetdrop® in a microfracture joint defect model in sheep

Timepoint 5211 (VECHCA) c(ng/ml) 5212 (VECHCA) c(ng/ml)
Day 0 (1 day prior surgery) 33.1 17.4
15 min. after 1st application (day 0) 33.0 18.0
20 min. after 1st application (day 0) 69.2 16.6
30 min. after 1st application (day 0) 35.7 12.1
1 h after 1st application (day 0) 40.5 13.7
2 h after 1st application (day 0) 76.4 14.9
3 h after 1st application (day 0) 120 20.0
6 h after 1st application (day 0) 178 28.4
18 h after 1st application (day 1) 342 81.9
Intra OP (day 1) 297 88.7
5 min. prior to 2nd application (day 3) 145 59.6
15 min. after 2nd application (day 3) 114 52.3
20 min. after 2nd application (day 3) 108 53.1
30 min. after 2nd application (day 3) 134 57.8
1 h after 2nd application (day 3) 135 58.9
2 h after 2nd application (day 3) 188 65.4
3 h after 2nd application (day 3) 269 85.8
6 h after 2nd application (day 3) 360 176
18 h after 2nd application (day 4) 572 353
6 h after application (week 1) 849 448
6 h after application (week 2) 882 365
6 h after application (week 3) 959 490
6 h after application (week 4) 949 525
6 h after application (week 5) 1327 580
6 h after application (week 6) 1347 391
1 week after the last application (week 7) 486 146