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Table 1 Carprofen concentrations of plasma samples Group 3 (VECA)

From: Preliminary study on carprofen concentration measurements after transcutaneous treatment with Vetdrop® in a microfracture joint defect model in sheep

Timepoint 5203 (VECA) c(ng/ml) 5204 (VECA) c(ng/ml)
Day 0 (1 day prior surgery) - -
15 min. after 1st application (day 0) - -
20 min. after 1st application (day 0) - -
30 min. after 1st application (day 0) <2.0 -
1 h after 1st application (day 0) 2.6 <2.0
2 h after 1st application (day 0) 5.5 4.1
3 h after 1st application (day 0) 7.2 7.7
6 h after 1st application (day 0) 19.1 16.8
18 h after 1st application (day 1) 72.0 54.1
Intra OP (day 1) 61.0 57.1
5 min. prior to 2nd application (day 3) 35.4 38.0
15 min. after 2nd application (day 3) 34.3 34.6
20 min. after 2nd application (day 3) 33.8 35.4
30 min. after 2nd application (day 3) 34.8 35.5
1 h after 2nd application (day 3) 33.8 36.2
2 h after 2nd application (day 3) 41.2 42.1
3 h after 2nd application (day 3) 46.8 46.4
6 h after 2nd application (day 3) 104 105
18 h after 2nd application (day 4) 187 325
6 h after application (week 1) 416 456
6 h after application (week 2) 419 347
6 h after application (week 3) 402 479
6 h after application (week 4) 301 376
6 h after application (week 5) 203 412
6 h after application (week 6) 343 675
1 week after the last application (week 7) 63.4 163