Efficacy, acceptability and tolerability of the new oral phosphate binder Lenziaren® in healthy cats fed a standard diet

Table 4 Summary of RMANCOVA analyses for control and Lenziaren® groups only (groups A-E)

Variable	Transformation	Normality P value	P values for model effects in RMANCOVA
			Treatment	Baseline*	Day	Treatment x day interaction	P < 0.05 in post hoc comparisons	Dose trend**
Body weight	Log	0.1698	0.9223	< 0.0001	0.4523	0.2702	None significant	0.31
Food consumed	Log	< 0.0001	0.0434	< 0.0001	0.9959	0.4724	B & C>>>D & E	0.91
Serum phosphate concentration	Log	0.5181	0.1501	< 0.0001	0.4910	0.4898	D > E	0.020 inc
Urine phosphate concentration	None	0.4201	0.0076	0.0005	0.0428	0.0455	C < E	0.0003 dec
Urine phosphate concentration	None	0.4201	0.0076	0.0005	0.0428	0.0455	D < A, B & E	0.0003 dec
Phosphorus consumed	None	< 0.0001	0.0266	< 0.0001	0.9904	0.4527	B & C > D & E	0.9299
Phosphorus excreted in faeces	Log	0.6280	0.4867	< 0.0001	< 0.0001	0.6309	None significant	0.4854
Phosphorus excreted in urine	Log	0.6590	0.0040	0.0001	0.0087	0.1695	B < A	0.0064 dec
Phosphorus excreted in urine	Log	0.6590	0.0040	0.0001	0.0087	0.1695	D < A, C & E	0.0064 dec
Total phosphorus excreted	Log	0.3264	0.1518	< 0.0001	< 0.0001	0.3878	A < D	0.0938
Phosphorus balance	Log	0.0242	0.2554	0.0184	< 0.0001	0.8813	A < D	0.0878
Fractional urinary phosphate excretion	None	0.6858	0.0001	< 0.0001	0.0222	0.8098	B & C < A & E	< 0.0001 dec
Fractional urinary phosphate excretion	None	0.6858	0.0001	< 0.0001	0.0222	0.8098	D < A, B, C & E	< 0.0001 dec

*The baseline used in the model was day −30 for body weight and serum phosphate concentration, and day −14 for all other variables.
**dec = decrease, inc = increase.
Values in bold indicate statistical significance (P < 0.05).

ISSN: 1746-6148