References | Schwartz-Porsche et al.[30] | Schwartz-Porsche et al.[15] | Cunningham et al.[29] | Löscher et al.[26] Rieck et al.[27] | Morton et al.[31] |
---|---|---|---|---|---|
AED evaluated | Primidone | ||||
2 nd AED | - | - | - | - | - |
3 rd AED | - | - | - | - | - |
4 th AED | - | - | - | - | - |
No of dogs | 30 | 20 | 15 | 26 | 12 |
Period of treatment (months) | Approx. 6 | mean, 14; range, 6.0-35 | 9 | mean, 6.0 ± 0.6 | Unclear |
Dose of AED(s) (mg/kg) | range, 13–100 PO SID | range, 17–107 PO SID | NA | mean, 51; range 24–70 PO SID | median, 50; mean, 48; range, 18–94 PO SID |
Pre-treatment SF (seizures/month) | NA | NA | NA | mean, 1.75 (over a period of 9 m) | median, 8; mean, 8.5; range, 0–20 (period was not reported) |
Post-treatment SF (seizures/month) | NA | NA | NA | mean, 0.59 | median, 0; mean 0.83; range, 0-8 |
No of dogs that were failures | 5/30 (17%) | 8/20 (40%) | 2/15 (13%) | 7/26 (27%) | - |
No of dogs with >0% - <50% reduction in SF | 5/30 (17%) | - | - | - | 2/12 (17%) |
No of dogs with ≥50% - <100% reduction in SF | 10/30 (33%) | 7/20 (35%) | 6/15 (40%) | 16/26 (62%) | - |
No of dogs with 100% reduction in SF | 10/30 (33%) | 5/20 (25%) | 7/15 (47%) | 4/26 (15%) | 10/12 (83%) |
No of dogs with >30% reduction in SF | 20/30 (67%) | 12/20 (60%) | 13/15 (87%) | 20/26 (77%) | 11/12 (92%) |
95% CI successfully treated cases | 50% - 83% | 39% - 81% | 70% - 100% | 61% - 93% | 62% - 100% |
Overall evidence for/against recommending the use of an AED | Insufficient evidence for recommending the use of primidone as a monotherapy AED |