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Table 7 Details of numbers of dogs, pre- and post- treatment seizure frequency, period of treatment, doses of AED(s), seizure frequency reduction/response after the initiation of treatment and efficacy statements for each study

From: Treatment in canine epilepsy – a systematic review

References Schwartz-Porsche et al.[30] Schwartz-Porsche et al.[15] Cunningham et al.[29] Löscher et al.[26]
Rieck et al.[27]
Morton et al.[31]
AED evaluated Primidone
2 nd AED - - - - -
3 rd AED - - - - -
4 th AED - - - - -
No of dogs 30 20 15 26 12
Period of treatment (months) Approx. 6 mean, 14; range, 6.0-35 9 mean, 6.0 ± 0.6 Unclear
Dose of AED(s) (mg/kg) range, 13–100 PO SID range, 17–107 PO SID NA mean, 51; range 24–70 PO SID median, 50; mean, 48; range, 18–94 PO SID
Pre-treatment SF (seizures/month) NA NA NA mean, 1.75 (over a period of 9 m) median, 8; mean, 8.5; range, 0–20 (period was not reported)
Post-treatment SF (seizures/month) NA NA NA mean, 0.59 median, 0; mean 0.83; range, 0-8
No of dogs that were failures 5/30 (17%) 8/20 (40%) 2/15 (13%) 7/26 (27%) -
No of dogs with >0% - <50% reduction in SF 5/30 (17%) - - - 2/12 (17%)
No of dogs with ≥50% - <100% reduction in SF 10/30 (33%) 7/20 (35%) 6/15 (40%) 16/26 (62%) -
No of dogs with 100% reduction in SF 10/30 (33%) 5/20 (25%) 7/15 (47%) 4/26 (15%) 10/12 (83%)
No of dogs with >30% reduction in SF 20/30 (67%) 12/20 (60%) 13/15 (87%) 20/26 (77%) 11/12 (92%)
95% CI successfully treated cases 50% - 83% 39% - 81% 70% - 100% 61% - 93% 62% - 100%
Overall evidence for/against recommending the use of an AED Insufficient evidence for recommending the use of primidone as a monotherapy AED
  1. AED(s), anti-epileptic drug(s); BID, bis in die (twice daily); Chloraz, Chlorazepate; CSF, cerebrospinal fluid; CL, confidence level; Diaz, Diazepam; Gaba, Gabapentin; IE, idiopathic epilepsy; LEV, Levetiracetam; m, month(s); NA, Not Available; PB, phenobarbital; PBr, potassium bromide; PO, per os; SF, seizure frequency; SID, semel in die (once daily); TID, ter in die (three times daily); TPM, Topiramate; w, week(s).