| |
MoDC
|
MoDC fold induction$
|
MoMΦ
|
MoMΦ fold induction
|
MoMΦ to MoDC
|
|---|
| |
Basal exp
|
STM
|
LPS
|
Basal exp
|
STM
|
LPS
|
NS
|
STM
|
LPS
|
|---|
|
IL1B
|
0.06 ± 0.04
|
106# ± 101
|
2358# ± 1268
|
0.11 ± 0.06
|
383# ± 451
|
1999# ± 1743
|
n
|
*
|
n
|
|
AMCF2
|
0.40 ± 0.20
|
35.3# ± 33.0
|
543# ± 528
|
0.75 ± 0.52
|
115# ± 107
|
305# ± 267
|
n
|
n
|
n
|
|
CXCL2
|
0.71 ± 0.28
|
17.4# ± 19.1
|
200# ± 161
|
0.19 ± 0.19
|
155# ± 102
|
668# ± 432
|
n
|
n
|
n
|
|
IL1A
|
0.28 ± 0.14
|
22.9# ± 25.3
|
229# ± 164
|
0.24 ± 0.12
|
86.5# ± 48.8
|
187# ± 57
|
n
|
**
|
n
|
|
IL8
|
15.3 ± 13.7
|
5.9 ± 5.74
|
34.2# ± 21.6
|
6.78 ± 5.95
|
22.9# ± 13.2
|
113# ± 66
|
n
|
n
|
n
|
|
ISG15
|
0.88 ± 0.52
|
2.94# ± 1.22
|
2.00 ± 0.94
|
0.17 ± 0.10
|
22.1# ± 2.0
|
78.9# ± 104.4
|
***
|
n
|
n
|
|
MARCKSL1
|
0.70 ± 0.60
|
1.82 ± 0.63
|
4.07# ± 2.30
|
0.25 ± 0.08
|
17.9# ± 9.1
|
42.9# ± 15.6
|
n
|
*
|
**
|
|
SOD2
|
4.28 ± 4.58
|
2.13 ± 0.80
|
12.8# ± 12.9
|
4.61 ± 2.55
|
11.3# ± 4.6
|
27.6# ± 11.6
|
n
|
**
|
n
|
|
IκBα
|
1.15 ± 0.36
|
2.74# ± 1.12
|
8.12# ± 3.10
|
1.13 ± 0.57
|
9.64# ± 3.72
|
15.1# ± 4.8
|
n
|
***
|
n
|
|
CD14
|
0.52 ± 0.19
|
3.84# ± 1.52
|
14.4# ± 9.6
|
0.35 ± 0.27
|
14.0# ± 9.7
|
18.0# ± 20.0
|
n
|
n
|
n
|
|
PPA1
|
1.34 ± 0.84
|
1.85# ± 0.7
|
4.83# ± 1.93
|
1.39 ± 0.17
|
4.42# ± 1.00
|
7.02# ± 1.73
|
n
|
***
|
n
|
|
CD48
|
7.35 ± 4.25
|
1.83 ± 0.22
|
3.2# ± 1.8
|
9.93 ± 2.43
|
3.34# ± 0.71
|
5.33# ± 1.90
|
n
|
*
|
*
|
|
NF-κB1
|
1.57 ± 0.41
|
1.82 ± 0.61
|
3.49# ± 1.4
|
1.97 ± 0.44
|
2.25# ± 0.7
|
4.63# ± 2.20
|
n
|
n
|
n
|
|
ANXA1
|
15.3 ± 4.7
|
1.78 ± 0.9
|
3.74# ± 1.91
|
22.9 ± 13.4
|
1.40 ± 0.38
|
2.45# ± 1.01
|
n
|
n
|
n
|
|
OPN
|
86.1 ± 42.8
|
2.33 ± 1.5
|
3.42# ± 2.27
|
138 ± 72
|
2.12 ± 1.20
|
3.81# ± 2.00
|
n
|
n
|
n
|
|
PFDN2
|
0.09 ± 0.03
|
1.54 ± 0.51
|
2.22# ± 0.63
|
0.12 ± 0.04
|
2.12# ± 0.60
|
2.63# ± 0.72
|
n
|
n
|
n
|
|
PSMB4
|
6.18 ± 1.58
|
1.42 ± 0.30
|
1.82# ± 0.31
|
7.34 ± 1.39
|
1.73 ± 0.40
|
2.11# ± 0.54
|
n
|
n
|
n
|
|
MoDC only
| | | | | | | | | |
|
OLDLR1
|
9.73 ± 3.74
|
1.95# ± 0.5
|
3.33# ± 0.91
|
26.2 ± 3.0
|
1.43 ± 0.42
|
1.62 ± 0.41
|
***
|
*
|
n
|
|
CDC42
|
3.52 ± 0.70
|
1.62# ± 0.33
|
1.63 ± 0.33
|
4.78 ± 1.43
|
1.60 ± 0.13
|
1.53 ± 0.61
|
n
|
n
|
n
|
|
MoMΦ only
| | | | | | | | | |
|
VCAM1
|
0.33 ± 0.25
|
2.32 ± 1.90
|
5.52 ± 4.51
|
0.18 ± 0.19
|
9.82# ± 6.24
|
18.9# ± 13.6
|
n
|
n
|
n
|
|
HMOX1
|
0.32 ± 0.20
|
2.32 ± 1.53
|
1.42 ± 0.51
|
0.45 ± 0.11
|
2.34# ± 1.11
|
2.44# ± 0.14
|
n
|
n
|
*
|
|
Serglycin
|
45.9 ± 19.9
|
1.52 ± 0.71
|
2.40 ± 1.03
|
35.7 ± 28.9
|
3.04# ± 1.32
|
2.84# ± 1.33
|
n
|
n
|
n
|
- $The fold inductions are presented as mean ± SD calculated based on ratios of individual treated samples relative to the mean of appropriate non-stimulated control.
- #The numbers signed with #represent significantly different results compared to non-stimulated (NS) cells.
- *Statistically significant differences between MoMΦ and MoDC with the same treatment. *p < 0.05; **p < 0.01; ***p < 0.001; n = non-significant.
