Figure 7

DOX-induced apoptosis and caspase-3 activation in DTK-E and DTK-SME cells. (A) Agarose gel electrophoresis of total cellular DNA showed DOX-induced DNA fragmentation (apoptosis) in CMT cells. Cells were incubated with 1000 mM DOX for 24 h, 48 h, and 72 h. M: DNA marker. (B) Western blots show DOX-induced activation of caspase-3 in CMT cells. Cells were incubated with 1000 nM DOX for 24 h and 48 h.