Figure 1
Radiolucent defect corresponds to areas of ischaemic chondronecrosis. Three-dimensional volume-reconstructed model (a), transverse CT slice (b) and transverse histological section (c, d) from the left distal femur of piglet 6 at the 5th examination interval. (a) There is a focal radiolucent defect within the ossification front of the medial femoral condyle (between arrows). (b) The defect from (a) is visible at the intersection of the solid green lines. (c) The radiolucent defect corresponds to 2 closely adjacent areas of ischaemic chondronecrosis located within the ossification front (between arrows). The stippled box indicates the location of the area that is shown at higher power magnification in (d). (d) The figure shows a necrotic cartilage canal (asterisks) surrounded by necrotic chondrocytes (arrows), i.e. ischaemic chondronecrosis. Adjacent viable chondrocytes are grouped together several cells within a single lacuna, interpreted as proliferation (arrowhead).