TY - JOUR AU - Sykes, Ben W. AU - Sykes, Katja M. AU - Hallowell, Gayle D. PY - 2014 DA - 2014/08/23 TI - Administration of trimethoprim-sulphadimidine does not improve healing of glandular gastric ulceration in horses receiving omeprazole: a randomised, blinded, clinical study JO - BMC Veterinary Research SP - 180 VL - 10 IS - 1 AB - Interest in Equine Gastric Ulcer Syndrome (EGUS) has recently increased in part due to a growing awareness of the differences between squamous and glandular disease. The pathophysiology and epidemiology of squamous and glandular disease are different and recently it has been shown that the response of glandular gastric ulceration to monotherapy with omeprazole is poor. Given these differences it has been recommended that specific treatment guidelines be formulated for equine glandular disease and that adjunctive therapies be investigated. Along these lines it has been suggested that the addition of antimicrobials may enhance healing. The objective of this study was to investigate whether the addition of trimethoprim-sulphadimidine to omeprazole therapy would result in superior healing of naturally occurring equine glandular ulceration compared with omeprazole monotherapy. SN - 1746-6148 UR - https://doi.org/10.1186/s12917-014-0180-0 DO - 10.1186/s12917-014-0180-0 ID - Sykes2014 ER -