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Table 2 MMP-9, MMP-2, MT1-MMP, TIMP-1, TIMP-2, VEGF-A, VEGF-164 and RECK mRNA expression in control lymph nodes, B-cell and T-cell lymphomas, CLBL-1 and OSW lymphoma cell lines

From: The role of vascular endothelial growth factor and matrix metalloproteinases in canine lymphoma: in vivo and in vitro study

Genes Control lymph nodes B-cell lymphoma T-cell lymphoma CLBL-1 OSW
MMP-2 0.96 ± 0.23a,b 0.24 ± 0.28 0.16 ± 0.29 0.00 0.00
TIMP-2 0.85 ± 0.34a,b 0.15 ± 0.20 0.16 ± 0.29 0.00 0.82
MT1-MMP 0.61 ± 0.17a 0.11 ± 0.11c 0.94 ± 0.99 0.04 4.11
MMP-9 0.13 ± 0.11b 0.12 ± 0.04 c 0.69 ± 0.11 0.76 1128.35
TIMP-1 0.15 ± 0.09b 0.16 ± 0.22 c 0.66 ± 0.75 0.72 2.38
RECK 0.29 ± 0.12b 0.06 ± 0.12c 0.87 ± 1.12 4.32 19.56
VEGF-A 0.37 ± 0.19b 0.71 ± 0.98 0.89 ± 1.37 4.87 1.42
VEGF-164 0.57 ± 0.23 0.63 ± 0.92 0.90 ± 1.38 7.99 3.18
  1. Data are expressed as relative quantification values (arbitrary units, mean ± SD).
  2. a, b, c Significant differences between control lymph nodes and B-cell lymphoma, control lymph nodes and T-cell lymphoma, B-cell lymphoma and T-cell lymphoma, respectively (Kruskal-Wallis test followed by Dunn’s post test; p < 0.05).