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Table 3 PrP Sc epitope mapping immunolabeling results of hemal nodes and retropharyngeal lymph nodes from naturally and experimentally scrapie-infected sheep

From: Accumulation profiles of PrPScin hemal nodes of naturally and experimentally scrapie-infected sheep

Animal ID Age (months) Source of scrapie Clinical status Prnp Anti-prion mAbs
12B2 P4 1E4 8G8 L42 SAF84 F99/97.6.1
(Hemal nodes/Lymph nodes)
3339 37 Natural Preclinical ARQ/ARQ / / / / / / /
4071 29 Natural Preclinical ARQ/ARQ / / / / / / /
3403 37 Natural Clinical ARQ/ARQ / / n / / / /
3727 NA Natural Clinical ARQ/ARQ / / / n / / /
3768 30 Natural Clinical ARQ/ARQ / / / / / / /
4063 29 Natural Clinical ARQ/VRQ / / / / / / /
2933 46 Natural Clinical ARQ/VRQ / / / / / / /
3588 30 Natural Clinical ARQ/VRQ / / / / / / /
3753 35 Natural Clinical VRQ/VRQ / / / / / / /
3755 12 Natural Clinical VRQ/VRQ / / n / / / /
3774 48 Natural Clinical VRQ/VRQ / / / / / / /
3776 50 Natural Clinical VRQ/VRQ / / / / / / /
3777 50 Natural Clinical VRQ/VRQ / / / / / / /
3806 28 Natural Clinical VRQ/VRQ / / / / / / /
3807 25 Natural Clinical VRQ/VRQ / / / / / / /
3823 13 Exp- BC Preclinical ARQ/ARQ / / / / / / /
3820 24 Exp- PRP Preclinical ARQ/ARQ n / n / / / /
3628 12 Exp- WB Preclinical ARQ/VRQ / / / / / / /
4132 13 Exp- WB Preclinical ARQ/VRQ / / / / / / /
4118 13 Exp- PBMC Preclinical ARQ/VRQ / / / / / / /
4494 16 Exp- PBMC Preclinical VRQ/VRQ / / / / / / /
4381 11 Exp- B cells* Preclinical VRQ/VRQ / / / / / / /
4382 11 Exp- B cells* Preclinical VRQ/VRQ / / n / / / /
4385 11 Exp- B cells Preclinical VRQ/VRQ / / / / / / /
4489 16 Exp- B cells Preclinical VRQ/VRQ / / / / / / /
  1. Abbreviations: Prnp = prion genotypes; NA = not available; EXP = experimental; PRP = platelet-rich plasma; BC = buffy coat; WB = whole blood; PBMC = peripheral blood mononuclear cells; * = CD21+ subset of B cells; blank = PrPSc labeling was detected; n = PrPSc labeling was not detected.