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Table 1 Relationships between tumour characteristics and expression of mTOR and p-mTOR

From: Activation of mammalian target of rapamycin (mTOR) in triple negative feline mammary carcinomas

Clinicopathologic characteristics

mTOR+

mTOR-

P

p-mTOR+

p-mTOR -

P

 

n(%)

n(%)

 

n(%)

n(%)

 

Triple negative

22 (42.31%)

9 (17.31%)

0.03

24 (41.38%)

7 (12.07%)

0.0005

Non-triple negative

11 (21.15%)

16 (30.77%)

 

8 (13.79%)

19 (32.76%)

 

Total

33

25

 

32

26

 
   

mTOR +

24 (41.38%)

8 (13.79%)

0.0032

   

mTOR -

9 (17.31%)

17 (29.31%)

 
    

32

26

 
   

*

  

***

HER2 +

7 (12.07%)

12 (20.69%)

0.0479

4 (6.9%)

15 (25.86%)

0.0005

HER2 -

26 (44.83%)

13 (22.41%)

 

28 (48.28%)

11 (18.97%)

 

Total

33

25

 

32

26

 

>1 cm

27 (46.55%)

16 (27.59%)

>0.05

22 (42.31%)

20 (30.48%)

0.05

≤1 cm

8 (13.79%)

7 (12.07%)

 

10 (17.24%)

6 (10.34%)

 
 

35

23

 

32

26

 

Grade I

5 (8.62%)

4 (6.90%)

>0.05

4 (6.90%)

5 (8.62%)

>0.05

Grade II

12 (20.69%)

12 (20.69%)

 

14 (24.14%)

10 (17.24%)

 

Grade III

16 (27.59%)

9 (15.52%)

 

14 (24.14%)

11 (21.15%)

 

Total

33

25

 

32

26

 

Vascular invasion

7 (12.07%)

7 (12.07%)

>0.05

6 (10.34%)

8 (13.79%)

>0.05

No vascular invasion

26 (44.83%)

18 (31.03%)

 

26 (44.83%)

18 (31.03)

 

Total

33

25

 

32

26

 

Relapsed

25 (43.10%)

20 (30.48%)

>0.05

17 (29.31%)

28 (48.28%)

>0.05

Not relapsed

8 (13.79%)

5 (8.62%)

 

7 (12.07%)

6 (10.34%)

 

Total

33

25

 

24

34

 

Relapsed 0–6 months

17 (37.78%)

14 (31.11%)

>0.05

9 (20.00%)

22 (48.89%)

>0.05

Relapsed 6–12 months

4 (8.89%)

3 (31.03%)

 

4 (8.89%)

3 (31.03%)

 

Relapsed >12 months

4 (8.89%)

3 (31.03%)

 

4 (8.89%)

4 (31.03%)

 

Total

25

20

 

17

28

 

Mitotic indexa 1

4 (6.90%)

2 (3.45%)

>0.05

3 (5.17%)

3 (5.17%)

>0.05

Mitotic index 2

7 (12.07%)

8 (13.79%)

 

8 (13.79%)

7 (12.07%)

 

Mitotic index 3

22 (42.31%)

15 (25.86%)

 

21 (36.21%)

16 (27.59%)

 

Total

33

25

 

32

26

 
  1. aMitotic index of the histological grading system [27].