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Table 1 Survival times of tg a 20 mice inoculated intracranially with serially diluted or treated RML brain homogenate

From: Exposure of RML scrapie agent to a sodium percarbonate-based product and sodium dodecyl sulfate renders PrPScprotease sensitive but does not eliminate infectivity

Dilution or treatment Mean survival time in days ± SD (% survival)
1) RML titration series *
100 65.5 ± 3.4 (0%)
10-1 73.6 ± 3.3 (0%)
10-2 83.2 ± 6.1 (0%)
10-3 195.4 ± 148.5 (22%)
10-4 394.8 ± 120.3 (78%)
10-5 through 10-12 455 (100%) – study termination
2) Treated RML
SPC-PL x 30 min 67.1 ± 2.6 (0%)
SPC-PL x 90 min 68.8 ± 4.6 (0%)
SPC-PL x 180 min 68.5 ± 2.8 (0%)
SPC-PH x 30 min 70.3 ± 6.0 (0%)
SPC-PH x 90 min 71.0 ± 5.1 (0%)
SPC-PH x 180 min 73.8 ± 3.2 (0%)
SPC-PL + SDS x 30 min 93 ± 9.7 (0%)
SPC-PL + SDS x 90 min 136.4 ± 72.2 (10%)
SPC-PL + SDS x 180 min 178.7 ± 92.4 (20%)
SPC-PH + SDS x 30 min 92.5 ± 7.6 (0%)
SPC-PH + SDS x 90 min 86.4 ± 6.9 (0%)
SPC-PH + SDS x 180 min 84.7 ± 11.1 (0%)
SDS x 30 min 84.9 ± 12.3 (0%)
SDS x 90 min 107.5 ± 40.5 (0%)
SDS x 180 min 85.7 ± 6.7 (0%)
  1. Abbreviations: SD, standard deviation; SPC-P L or H , low or high concentration sodium percarbonate-based product; SDS, sodium dodecyl sulfate.
  2. *1% w/v starting (100) concentration.