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Table 2 Over-represented cellular pathways in canine mammary cancer

From: Gene expression profiles in canine mammary carcinomas of various grades of malignancy

Cellular pathway

1vs 2

1vs 3

2vs 3

5HT1 type receptor mediated signaling pathway

X

X

 

Acetate utilization

 

X

X

Alzheimer disease-amyloid secretase pathway

 

X

 

Angiogenesis

 

X

X

Apoptosis signaling pathway

X

X

X

Axon guidance mediated by semaphorins

 

X

X

Beta1 adrenergic receptor signaling pathway

X

X

 

Beta2 adrenergic receptor signaling pathway

X

X

 

Cadherin signaling pathway

 

X

X

Cytoskeletal regulation by Rho GTPase

 

X

X

DNA replication

 

X

X

Endothelin signaling pathway

 

X

X

GABA-B_receptor_II_signaling

X

X

 

Glycolysis

X

X

X

Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway

X

X

X

Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway

X

X

 

Histamine H2 receptor mediated signaling pathway

X

X

 

Huntington disease

 

X

X

Inflammation mediated by chemokine and cytokine signaling pathway

X

X

X

Interleukin signaling pathway

 

X

X

Metabotropic glutamate receptor group II pathway

X

X

 

Metabotropic glutamate receptor group III pathway

X

X

 

Muscarinic acetylcholine receptor 2 and 4 signaling pathway

X

X

 

P53 pathway feedback loops 1

X

X

 

PDGF signaling pathway

X

X

 

PI3 kinase pathway

X

X

X

Pentose phosphate pathway

X

X

 

Ras Pathway

X

X

 

Transcription regulation by bZIP transcription factor

 

X

X

VEGF signaling pathway

 

X

X

Wnt signaling pathway

X

X

X

p53 pathway feedback loops 2

 

X

X

p53 pathway

 

X

X

  1. Cellular pathways in which are involved significantly up-regulated genes in the examined tumour groups. The analysis was conducted using PANTHER Database (http://www.pantherdb.org). The pathway activity in the tumour group 1 vs 2, 1 vs 3 and 2 vs 3 is marked as X.