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Table 4 Multivariate Cox proportional hazard analysis of clinicopathologic variables for ovarall survival rate

From: Expression of autophagy-related protein beclin-1 in malignant canine mammary tumors

  Multivariate analysis
  Hazard ratio 95% confidence interval p value
Age (> 11 years vs. 11 years) 1.460 0.683 - 3.124 0.329
Tumor size (> 3 cm vs. 3 cm) 3.038 1.298 - 7.108 0.010*
Tubular formation (> 10% vs. 10%) 0.364 0.167 - 0.794 0.011*
Nuclear pleomorphism (high vs. low) 1.001 0.445 - 2.253 0.997
Mitotic count (> 11 vs. 10/10 HPFs) 0.881 0.166 - 4.676 0.882
Histologic grade (3 vs. 2 and 1) 0.627 0.088 - 4.486 0.642
Lymphovascular invasion (yes vs. no) 2.286 0.887 - 5.887 0.087
Necrosis (extensive vs. limited/no) 0.977 0.473 - 2.019 0.951
Estrogen receptor (negative vs. positive) 0.499 0.232 - 1.076 0.076
Her2/neu overexpression (positive vs. negative) 2.433 0.950 - 6.234 0.064
Beclin-1 cytoplasmic expression (low vs. high) 2.752 1.211 - 6.256 0.016*
Beclin-1 nuclear expression (low vs. high) 1.471 0.667 - 3.243 0.339
  1. * p < 0.05.