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Table 4 Combined effect of the haplotypes of the two ESR1 LD blocks in ESS cases and controls

From: The ESR1 gene is associated with risk for canine mammary tumours

Haplotype combination Frequency Haplotype comparison OR (95% CI) P Raw a P Bonf b
  Cases Controls     
TA-GTG (risk) 207 97 Risk TA-GTG vs. rest 1.8 (1.2 - 2.8) 0.007 0.077
    Risk TA-GTG vs. protective CA-ACA 3.3 (1.4 - 7.9) 0.005 0.055
CA-ACA (protective) 9 14 Protective CA-ACA vs. rest 0.3 (0.1 - 0.8) 0.010 0.110
Other c 56 41     
  1. a Fisher-Exact test applied due to low counts of the CG haplotype (less than five in both cases and controls).
  2. b Corrected for the number of LD blocks (11).
  3. c For 29 cases and 18 controls, the haplotype combinations could not be fully determined due to genotyping failure of one or more of the ESR1 SNPs.
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