The ESR1 gene is associated with risk for canine mammary tumours

BMC Veterinary Research

Table 4 Combined effect of the haplotypes of the two ESR1 LD blocks in ESS cases and controls

Haplotype combination	Frequency		Haplotype comparison	OR (95% CI)	P _Raw ^a	P _Bonf ^b
	Cases	Controls
TA-GTG (risk)	207	97	Risk TA-GTG vs. rest	1.8 (1.2 - 2.8)	0.007	0.077
			Risk TA-GTG vs. protective CA-ACA	3.3 (1.4 - 7.9)	0.005	0.055
CA-ACA (protective)	9	14	Protective CA-ACA vs. rest	0.3 (0.1 - 0.8)	0.010	0.110
Other ^c	56	41

^a Fisher-Exact test applied due to low counts of the CG haplotype (less than five in both cases and controls).
^b Corrected for the number of LD blocks (11).
^c For 29 cases and 18 controls, the haplotype combinations could not be fully determined due to genotyping failure of one or more of the ESR1 SNPs.

ISSN: 1746-6148