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Table 3 CMT-associated ESR1 haplotypes in the ESS cases and controls

From: The ESR1 gene is associated with risk for canine mammary tumours

Haplotype

Frequency

P Raw a

P Bonf b

P Perm c

OR

 

Total

Cases

Controls

    

ESR1 EX 2 and ESR1 EX 4 (rs21960513 and ss244244343)

TA

0.668

0.701

0.610

0.035

0.381

0.549

1.5

CA

0.318

0.293

0.363

0.098

1.000

0.941

0.7

CG

0.014

0.006

0.027

0.052

0.572

0.741

0.2

ESR1 INT 7-8a, –b and ESR1 EX 8 (ss244244344, ss244244345 and ss244244346)

GTG

0.791

0.818

0.744

0.047

0.517

0.683

1.5

ACA

0.091

0.070

0.129

0.024

0.264

0.480

0.5

  1. aP-value from chi-square test in Haploview.
  2. b Corrected for the number of LD blocks available (11).
  3. c Permutation P-value from Haploview, 10,000 permutations.