Figure 1From: Synovial distribution of “systemically” administered acetylsalicylic acid in the isolated perfused equine distal limbASA concentrations in the synovial fluid of the fetlock joint in the isolated perfused equine distal limb after imitated systemic administration of 20 mg/kg ASA. Synovial fluid concentrations were measured using microdialysis and HPLC and are given as mean ± S.E.M of 6 (tyrode perfusion) or 2 (hemoperfusion) independent experiments. ASA EC50 values for COX I and COX II (Buntenkötter, 2012) are indicated to assess the anti-inflammatory effect of the synovial concentrations.Back to article page