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Table 5 Pharmakokinetik/Pharmakodynamic ratios of oral pradofloxacin values (3 mg/kg oral administration) in serum and ISF

From: Pharmacokinetic study on pradofloxacin in the dog – Comparison of serum analysis, ultrafiltration and tissue sampling after oral administration

  Pasteurella multocida(MIC90= 0.015 μg/ml) Escherichia coli(MIC90= 0.03 μg/ml) Staphylococcus pseudintermedius(MIC90= 0.12 μg/ml)
  Serum ISF Serum ISF Serum ISF
Cmax/MIC90 123.3 103.3 61.7 51.7 15.4 12.9
AUC0-24/MIC90 1078.7 1412.7 539.3 706.3 134.8 176.6