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Table 3 Pharmacokinetic parameters (mean ± SD) for pradofloxacin after oral administration (6 mg/kg) in dogs

From: Pharmacokinetic study on pradofloxacin in the dog – Comparison of serum analysis, ultrafiltration and tissue sampling after oral administration

Parameter Units PO Serum PO ISF
C max μg/ml 2.77±0.63# 2.71±0.8#
AUC 24 h*μg/ml 24.21±5.09 35.19±8.39
AUCi nf h*μg/ml 26.76±6.27# 43.38±17.54#
T max h 2±1.1* 6±3.35*
T 1/2 h 6.31±1.74# 8.35±3.5#
T 24 h 24±0 24±0
λ z /h 0.12±0.03 0.09±0.03
MRT last h 7.16±1.31 10.16±1.83
MRT inf h 9.58±3.04 14.6±6.41
  1. Cmax maximum concentration; AUC24 area under the curve from time 0 to 24 hours; MRTlast mean residence time; λz first order rate constant of terminal portion of the curve; T1/2 half-life; Tmax time to maximal concentration; T 24 time of final measurement; AUCinf area under the curve from 0 extrapolated to infinity; MRTinf mean residence time from time 0 extrapolated to infinity for non-infusion models; * statistical different (p ≤ 0,05); # no statistical difference (p ≤ 0,05).