Pharmacokinetic study on pradofloxacin in the dog – Comparison of serum analysis, ultrafiltration and tissue sampling after oral administration

Table 3 Pharmacokinetic parameters (mean ± SD) for pradofloxacin after oral administration (6 mg/kg) in dogs

Parameter	Units	PO Serum	PO ISF
C _max	μg/ml	2.77±0.63^#	2.71±0.8^#
AUC ₂₄	h*μg/ml	24.21±5.09	35.19±8.39
AUCi _nf	h*μg/ml	26.76±6.27^#	43.38±17.54^#
T _max	h	2±1.1^*	6±3.35*
T _1/2	h	6.31±1.74^#	8.35±3.5^#
T ₂₄	h	24±0	24±0
λ _z	/h	0.12±0.03	0.09±0.03
MRT _last	h	7.16±1.31	10.16±1.83
MRT _inf	h	9.58±3.04	14.6±6.41

C_max maximum concentration; AUC₂₄ area under the curve from time 0 to 24 hours; MRT_last mean residence time; λ_z first order rate constant of terminal portion of the curve; T_1/2 half-life; T_max time to maximal concentration; T ₂₄ time of final measurement; AUC_inf area under the curve from 0 extrapolated to infinity; MRT_inf mean residence time from time 0 extrapolated to infinity for non-infusion models; * statistical different (p ≤ 0,05); # no statistical difference (p ≤ 0,05).

ISSN: 1746-6148