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Table 2 Pharmacokinetic parameters (mean ± SD) for pradofloxacin after oral administration (3 mg/kg) in dogs

From: Pharmacokinetic study on pradofloxacin in the dog – Comparison of serum analysis, ultrafiltration and tissue sampling after oral administration

Parameter Units PO Serum PO ISF
C max μg/ml 1.85±0.23* 1.55±0.31*
AUC 24 h*μg/ml 16.18±4.28 21.19±8.12
AUCi nf h*μg/ml 18.11±4.82# 29.95±11.41#
T max h 2.33±1.37* 8±3.27*
T 1/2 h 6.97±1.83# 8.57±2.29#
T 24 h 24±0 21±6
λ z /h 0.11±0.03 0.08±0.02
MRT last h 7.9±0.81 10.35±3.39
MRT inf h 11.27±3.11 14.78±4.12
  1. Cmax maximum concentration; AUC24 area under the curve from time 0 to 24 hours; MRTlast mean residence time; λz first order rate constant of terminal portion of the curve; T1/2 half-life; Tmax time to maximal concentration; T 24 time of final measurement; AUCinf area under the curve from 0 extrapolated to infinity; MRTinf mean residence time from time 0 extrapolated to infinity for non-infusion models; * statistical different (p ≤ 0,05); # no statistical difference (p ≤ 0,05).