Pharmacokinetic study on pradofloxacin in the dog – Comparison of serum analysis, ultrafiltration and tissue sampling after oral administration

Table 2 Pharmacokinetic parameters (mean ± SD) for pradofloxacin after oral administration (3 mg/kg) in dogs

Parameter	Units	PO Serum	PO ISF
C _max	μg/ml	1.85±0.23^*	1.55±0.31*
AUC ₂₄	h*μg/ml	16.18±4.28	21.19±8.12
AUCi _nf	h*μg/ml	18.11±4.82^#	29.95±11.41^#
T _max	h	2.33±1.37^*	8±3.27*
T _1/2	h	6.97±1.83^#	8.57±2.29^#
T ₂₄	h	24±0	21±6
λ _z	/h	0.11±0.03	0.08±0.02
MRT _last	h	7.9±0.81	10.35±3.39
MRT _inf	h	11.27±3.11	14.78±4.12

C_max maximum concentration; AUC₂₄ area under the curve from time 0 to 24 hours; MRT_last mean residence time; λ_z first order rate constant of terminal portion of the curve; T_1/2 half-life; T_max time to maximal concentration; T ₂₄ time of final measurement; AUC_inf area under the curve from 0 extrapolated to infinity; MRT_inf mean residence time from time 0 extrapolated to infinity for non-infusion models; * statistical different (p ≤ 0,05); # no statistical difference (p ≤ 0,05).

ISSN: 1746-6148