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Table 4 Comparison of rabies viral antigen and RNA in major CNS regions in canine furious rabies

From: Reduced viral burden in paralytic compared to furious canine rabies is associated with prominent inflammation at the brainstem level

  Spinal cord Brainstem Cerebellum Cerebral midline Cerebrum
  (Mean ± SD) P value (Mean ± SD) P value (Mean ± SD) P value (Mean ± SD) P value (Mean ± SD) P value
% RABV antigen-positive neurons           
Spinal cord 97.32 ± 1.09    0.013   0.013   0.013   0.013
Brainstem   0.013 72.17 ± 14.99    0.377   0.024   0.014
Cerebellum   0.013   0.377 68.0 ± 14.07    0.038   0.014
Cerebral midline   0.013   0.024   0.038 49.69 ± 17.72    0.125
Cerebrum   0.013   0.014   0.014   0.125 36.75 ± 19.18  
% RABV antigen area in positive neuron           
Spinal cord 8.55 ± 2.7    0.228   0.026   0.013   0.026
Brainstem   0.228 7.62 ± 2.49    0.014   0.004   0.023
Cerebellum   0.026   0.014 2.97 ± 2.67    0.174   0.125
Cerebral midline   0.013   0.004   0.174 3.01 ± 0.43    0.301
Cerebrum   0.026   0.024   0.125   0.301 3.77 ± 1.62  
% RABV antigen-positive area per neuron           
Spinal cord 8.35 ± 2.7    0.089   0.026   0.013   0.013
Brainstem   0.089 5.95 ± 2.75    0.024   0.008   0.014
Cerebellum   0.026   0.024 2.16 ± 2.36    0.232   0.458
Cerebral midline   0.013   0.008   0.232 1.67 ± 0.72    0.338
Cerebrum   0.013   0.014   0.458   0.338 1.63 ± 1.29  
RABV RNA (copies/μg total RNA) × 108           
Spinal cord 3.16 ± 3.04    0.089   0.327   0.148   0.148
Brainstem   0.089 6.66 ± 3.57    0.024   0.301   0.174
Cerebellum   0.327   0.024 2.66 ± 2.18    0.059   0.174
Cerebral midline   0.148   0.301   0.059 7.64 ± 5.81    0.232
Cerebrum   0.148   0.174   0.174   0.232 5.69 ± 4.89  
  1. Underlined P values indicate significant difference.