Table 2 Mean number of worms (range) and efficacy (%) from necropsy performed 14 days after the intraruminal administration of the reference (RF) and each of test generic (Test 1 and Test 2) ivermectin formulations at 200 μg/kg in nematode infected lambs (n=6)
Parasites | Reference | Test 1 | Test 2 | Untreated control | |||
|---|---|---|---|---|---|---|---|
Worm counts | Efficacy (%) | Worm counts | Efficacy (%) | Worm counts | Efficacy (%) | Worm counts | |
Abomasum | |||||||
Haemonchus spp. | 3210 | 7 | 3117 | 8 | 2514 | 27 | 3362 |
(2190-4430) | (1920-3850) | (1591-3950) | (2680-4360) | ||||
Teladorsagia circumcincta | 292 | 39 | 189 | 57 | 272 | 44 | 520 |
(90-530) | (100-310) | (680-130) | (240-1460) | ||||
Trichostrongylus axei | 73 | 96 | 47 * | 96 | 140 | 97 | 375 |
(0-220) | (0-160) | (0-440) | (80-1160) | ||||
Small intestine | |||||||
Trichostrongylus columbriformis | 10 * | 100 | 20 | 94 | 3 * | 100 | 140 |
(0-40) | (0-50) | (0-10) | (10-380) | ||||
Cooperia spp. | 40 | 80 | 28 | 38 | 17 | 61 | 70 |
(0-150) | (0-50) | (0-40) | (0-190) | ||||
Nematodirus spp. | 25 | 83 | 38 | 78 | 5 * | 100 | 278 |
(0-60) | (0-90) | (0-30) | (0-980) | ||||
Large intestine | |||||||
Oesophagostomun spp. | 0 * | 100 | 0 * | 100 | 0 * | 100 | 16 |
(0-0) | (0-1) | (0-0) | (2-19) | ||||
Trichuris ovis | 0 * | 100 | 0 * | 100 | 0 * | 100 | 5 |
(0-0) | (0-0) | (0-0) | (2-10) | ||||