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Table 2 Mean number of worms (range) and efficacy (%) from necropsy performed 14 days after the intraruminal administration of the reference (RF) and each of test generic (Test 1 and Test 2) ivermectin formulations at 200 μg/kg in nematode infected lambs (n=6)

From: Relative bioavailability and comparative clinical efficacy of different ivermectin oral formulations in lambs

Parasites Reference Test 1 Test 2 Untreated control
  Worm counts Efficacy (%) Worm counts Efficacy (%) Worm counts Efficacy (%) Worm counts
Abomasum        
Haemonchus spp. 3210 7 3117 8 2514 27 3362
  (2190-4430)   (1920-3850)   (1591-3950)   (2680-4360)
Teladorsagia circumcincta 292 39 189 57 272 44 520
  (90-530)   (100-310)   (680-130)   (240-1460)
Trichostrongylus axei 73 96 47 * 96 140 97 375
  (0-220)   (0-160)   (0-440)   (80-1160)
Small intestine        
Trichostrongylus columbriformis 10 * 100 20 94 3 * 100 140
  (0-40)   (0-50)   (0-10)   (10-380)
Cooperia spp. 40 80 28 38 17 61 70
  (0-150)   (0-50)   (0-40)   (0-190)
Nematodirus spp. 25 83 38 78 5 * 100 278
  (0-60)   (0-90)   (0-30)   (0-980)
Large intestine        
Oesophagostomun spp. 0 * 100 0 * 100 0 * 100 16
  (0-0)   (0-1)   (0-0)   (2-19)
Trichuris ovis 0 * 100 0 * 100 0 * 100 5
  (0-0)   (0-0)   (0-0)   (2-10)
  1. The percentage of efficacy was calculated using geometric mean as suggested by Wood et al. (1995).
  2. * Nematode counts are statistically different (P< 0.05) compared to counts obtained in the untreated control group.