From: Multicenter clinical evaluation of a multi-dose formulation of propofol in the dog
Treatment group | Total | ||||||
---|---|---|---|---|---|---|---|
1 | 2 | 3 | 4 | 5 | 6 | ||
Number of patients in group | 23 | 25 | 25 | 22 | 22 | 21 | 138 |
Number of patients receiving atropine | 0 | 0 | 1 | 10 | 21 | 6 | 38 |
Side effect (Adverse event) | No. patients experiencing side effect or adverse event ( ) | ||||||
Hypotension | 1 (1) | 1 (1) | 3 (2) | 9 (1) | 2 (2) | 16 (7) | |
Apnea | 1 (2) | 6 (6) | 2 (1) | 3 (2) | 3 (1) | 15 (12) | |
Bradycardia | 1 (1) | 1 (1) | 2 (1) | 1 | 1 | 6 (6) | 11 (9) |
Excitation | 1 | 2 | 1 | 6 | 2 | 1 | 13 |
Tachypnea | 1 | 2 | 3 | 1 | 7 | ||
Arrhythmias | 1 (1) | 1 | 2 (1) | ||||
Paddling | 2 | 1 | 1 | 4 | |||
Fasciculation | 2 | 1 | 1 | 4 | |||
Tenseness | 1 | 1 | 1 | 3 | |||
Hypertension | 3 | 3 | |||||
Cyanosis | 1 | 1 (1) | 2 (1) | ||||
Tachycardia | 1 | 1 | 2 | ||||
Salivation | 1 | 1 | 2 | ||||
Emesis | 1 (1) | 1 (1) | |||||
Death | (1) | 1 (1) |