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Table 6 Number of animals per group with side effects* or adverse events** recorded during the study

From: Multicenter clinical evaluation of a multi-dose formulation of propofol in the dog

 

Treatment group

Total

1

2

3

4

5

6

Number of patients in group

23

25

25

22

22

21

138

Number of patients receiving atropine

0

0

1

10

21

6

38

Side effect (Adverse event)

No. patients experiencing side effect or adverse event ( )

Hypotension

 

1 (1)

1 (1)

3 (2)

9 (1)

2 (2)

16 (7)

Apnea

1 (2)

6 (6)

2 (1)

3 (2)

3 (1)

 

15 (12)

Bradycardia

1 (1)

1 (1)

2 (1)

1

1

6 (6)

11 (9)

Excitation

1

2

1

6

2

1

13

Tachypnea

1

2

 

3

1

 

7

Arrhythmias

   

1 (1)

1

 

2 (1)

Paddling

2

1

   

1

4

Fasciculation

 

2

 

1

 

1

4

Tenseness

1

1

1

   

3

Hypertension

     

3

3

Cyanosis

1

   

1 (1)

 

2 (1)

Tachycardia

   

1

1

 

2

Salivation

1

    

1

2

Emesis

    

1 (1)

 

1 (1)

Death

    

(1)

 

1 (1)

  1. *Quantitative side effects defined as physiological measurements outside the normal range.
  2. **Quantitative adverse reactions defined as: heart rate less than 50 bpm, apnea >120 seconds, mean arterial blood pressure < 50 mmHg, any potentially lethal ECG rhythm, mean O2 saturation <80% (any duration) or 90% for > 3 min.