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Table 3 Mean ± SD of physiological variable measurements by treatment group

From: Multicenter clinical evaluation of a multi-dose formulation of propofol in the dog

Variable

Group

Immediately prior to premedication

Immediately prior to induction

Immediately post-induction

Minutes post-induction

5 min

10 min

20 min

30 min

Heart rate (beats per min) (N)1

1

NA (0)

117.2 ± 32.6 (22)

118.0 ± 27.1 (21)

123.7 ± 26.2 (20)

119.7 ± 28.7 (18)

112.9 ± 21.4 (10)

114.8 ± 18.5 (5)

2

113.0 ± 31.0 (25)

112.8 ± 32.2 (25)

116.3 ± 36.2 (23)

110.0 ± 28.7 (21)

112.1 ± 25.4 (19)

101.8 ± 26.7 (17)

94.2 ± 18.5 (14)

3

107.6 ± 28.9 (25)

96.9 ± 25.8 (25)

99.5 ± 34.1 (25)

101.0 ± 30.7 (23)

100.3 ± 26.3 (24)

103.4 ± 22.3 (16)

99.4 ± 19.1 (7)

4

127.8 ± 31.3 (22)

135.9 ± 35.0 (22)

146.8 ± 28.2 (20)

146.8 ± 30.9 (19)

141.7 ± 27.4 (18)

126.7 ± 26.0 (18)

123.1 ± 20.1 (19)

5

116.8 ± 18.9 (22)

145.1 ± 44.0 (22)

142.9 ± 37.3 (21)

158.1 ± 32.0 (20)

134.2 ± 25.2 (21)

124.2 ± 23.6 (21)

114.5 ± 23.4 (20)

6

115.6 ± 33.5 (21)

88.4 ± 36.9 (21)

94.9 ± 27.4 (20)

104.1 ± 26.3 (19)

102.6 ± 22.3 (19)

103.1 ± 20.4 (19)

95.1 ± 18.8 (18)

Statistical results2

None

4 > (3, 6); 5 > (2, 3, 6)

4 > (2, 3, 6); 5 > (3, 6)

4 > (2, 3, 6); 5 > (1–3, 6)

4 > (2, 3, 6); 5 > (3, 6)

4 > (2, 3, 6); 5 > (3, 6)

4 > (2, 3, 6); 5 > (3, 6)

Respiratory rate (breaths per min)

1

NA

41.6 ± 13.8

28.6 ± 24.0

31.2 ± 16.7

32.3 ± 26.6

22.6 ± 11.5

23.5 ± 9.8

2

41.1 ± 13.7

36.4 ± 14.9

26.1 ± 15.5

27.1 ± 18.7

30.7 ± 19.9

32.1 ± 18.4

27.0 ± 15.2

3

30.6 ± 13.7

30.3 ± 13.3

23.0 ± 15.2

24.6 ± 11.6

29.3 ± 11.6

27.8 ± 10.8

26.4 ± 15.3

4

34.8 ± 12.0

34.4 ± 11.8

23.9 ± 18.8

25.7 ± 13.3

24.9 ± 19.9

23.3 ± 21.7

26.5 ± 16.9

5

28.6 ± 6.2

29.9 ± 17.5

12.6 ± 9.8

17.4 ± 15.3

17.0 ± 11.6

14.0 ± 6.3

12.6 ± 8.6

6

42.4 ± 17.5

30.7 ± 23.6

12.2 ± 4.5

13.8 ± 6.4

13.8 ± 7.1

14.7 ± 6.7

12.9 ± 5.9

Statistical results2

6 > 5

None

1 > (5, 6)

(1, 2) > 6

(1, 2, 3) > 6

(2, 3) > 5; 2 > 6

(2, 3, 4) > 5; (2, 4) > 6

Systolic blood pressure (mmHg)

1

NA

148.0 ± 28.8

128.1 ± 19.9

128.2 ± 32.8

127.2 ± 21.5

115.7 ± 18.2

112.8 ± 14.8

2

141.8 ± 21.3

135.0 ± 30.6

119.6 ± 24.7

113.2 ± 24.0

115.3 ± 28.0

111.1 ± 20.8

115.9 ± 24.4

3

136.6 ± 23.4

126.2 ± 33.6

112.3 ± 21.0

108.8 ± 18.5

112.2 ± 18.7

106.9 ± 17.3

106.1 ± 15.5

4

129.6 ± 23.1

137.4 ± 24.9

122.7 ± 21.3

108.8 ± 15.3

106.4 ± 17.3

105.6 ± 26.7

108.6 ± 31.8

5

137.2 ± 22.3

134.5 ± 16.5

124.4 ± 15.2

112.1 ± 17.1

100.9 ± 11.1

99.8 ± 14.7

101.3 ± 13.7

6

137.1 ± 26.6

128.9 ± 34.5

125.9 ± 40.1

116.2 ± 39.4

127.9 ± 52.1

124.5 ± 36.2

116.6 ± 26.3

Statistical results2

None

None

None

None

(1, 6) > 5

6 > 5

None

Diastolic blood pressure (mmHg)

1

NA

91.5 ± 33.6

81.1 ± 21.1

79.7 ± 32.2

82.8 ± 22.6

69.4 ± 14.9

74.0 ± 23.8

2

89.0 ± 18.4

86.8 ± 22.8

77.1 ± 27.5

71.2 ± 16.2

73.3 ± 19.0

71.8 ± 22.9

75.1 ± 21.8

3

92.4 ± 26.1

76.9 ± 27.4

70.4 ± 24.0

63.5 ± 18.5

63.8 ± 15.4

57.7 ± 21.3

58.7 ± 15.5

4

87.1 ± 25.8

90.6 ± 28.6

76.2 ± 17.2

62.9 ± 11.6

57.9 ± 15.4

57.6 ± 19.8

60.6 ± 21.6

5

98.8 ± 18.3

89.0 ± 17.8

74.3 ± 19.0

61.3 ± 16.6

55.1 ± 4.6

53.9 ± 9.1

53.2 ± 8.6

6

98.4 ± 25.0

91.4 ± 31.3

90.0 ± 33.6

76.8 ± 35.2

88.2 ± 44.4

79.2 ± 29.2

71.8 ± 20.5

Statistical results2

None

None

None

None

1 > 5; 6 > (3, 4, 5)

6 > (3, 4, 5)

(2, 6) > 5

Mean blood pressure (mmHg)

1

NA

114.7 ± 27.1

100.2 ± 17.7

101.9 ± 31.7

99.9 ± 20.8

88.1 ± 14.8

90.0 ± 21.4

2

108.9 ± 17.3

102.3 ± 21.0

95.3 ± 24.2

85.8 ± 16.4

90.4 ± 26.0

87.5 ± 21.2

90.4 ± 24.1

3

107.8 ± 24.8

96.2 ± 27.9

86.3 ± 21.3

83.7 ± 16.4

85.5 ± 13.9

78.4 ± 20.7

81.1 ± 16.3

4

103.7 ± 23.8

109.8 ± 25.2

94.4 ± 18.7

78.0 ± 13.6

77.8 ± 15.4

76.6 ± 19.1

77.8 ± 22.0

5

113.1 ± 20.1

105.6 ± 14.3

92.0 ± 18.0

79.7 ± 17.4

72.4 ± 8.9

69.5 ± 9.5

70.3 ± 10.4

6

115.1 ± 24.8

107.1 ± 31.5

105.1 ± 36.2

92.6 ± 33.4

105.6 ± 44.9

99.5 ± 30.5

90.9 ± 19.3

Statistical results2

None

None

None

1 > (4, 5)

1 > 5; 6 > (4,5)

6 > (3, 4, 5)

(2, 6) > 5

Hb Ox Sat (%)

1

NA

NA

90.0 ± 9.9

94.3 ± 3.0

94.5 ± 2.7

95.9 ± 2.2

97.3 ± 1.7

2

NA

NA

90.1 ± 6.7

91.8 ± 6.7

93.4 ± 3.5

94.8 ± 2.7

97.7 ± 2.4

3

NA

NA

93.9 ± 4.3

94.0 ± 3.9

94.6 ± 2.7

94.8 ± 3.2

97.5 ± 2.4

4

NA

NA

95.7 ± 2.4

95.8 ± 2.1

96.7 ± 2.0

96.8 ± 1.7

95.4 ± 1.8

5

NA

NA

96.5 ± 1.9

97.6 ± 1.2

97.2 ± 1.5

97.2 ± 1.8

97.0 ± 1.7

6

NA

NA

95.6 ± 3.6

96.0 ± 2.4

95.7 ± 2.6

96.5 ± 2.6

96.5 ± 2.6

Statistical results2

-

-

(4, 5, 6) > (1, 2)

(4, 5, 6) > (1, 2)

(4, 5, 6) > 2; 5 > 3

5 > (2, 3)

None

End-tidal CO2 (%)

1

NA

NA

28.9 ± 7.9

31.7 ± 8.3

32.5 ± 7.9

36.3 ± 5.5

40.3 ± 9.2

2

NA

NA

34.8 ± 12.7

34.1 ± 8.0

38.2 ± 9.2

38.0 ± 9.4

40.4 ± 12.2

3

NA

NA

31.6 ± 9.9

35.9 ± 9.8

36.0 ± 7.2

37.7 ± 9.6

47.0 ± 9.6

4

NA

NA

34.6 ± 12.2

37.2 ± 9.4

36.8 ± 9.9

36.6 ± 8.7

38.7 ± 5.7

5

NA

NA

30.5 ± 7.9

33.7 ± 6.3

36.5 ± 5.9

37.4 ± 4.6

38.4 ± 4.4

6

NA

NA

37.0 ± 9.2

41.4 ± 7.3

40.8 ± 9.3

42.0 ± 8.0

43.8 ± 8.2

Statistical results1

-

-

None

6 > 1

6 > 1

None

None

Rectal temp. (deg. F)

1

NA

101.7 ± 0.7

101.2 ± 0.8

100.9 ± 0.9

100.4 ± 0.9

100.1 ± 1.2

99.8 ± 1.0

2

101.4 ± 0.7

101.3 ± 0.7

100.8 ± 0.8

100.4 ± 0.7

100.1 ± 0.7

99.8 ± 0.8

99.5 ± 0.8

3

101.3 ± 0.8

100.9 ± 0.7

100.3 ± 0.8

100.0 ± 1.0

99.8 ± 1.3

99.5 ± 1.3

99.1 ± 1.6

4

101.5 ± 0.8

101.2 ± 0.7

100.3 ± 1.3

100.3 ± 0.8

100.2 ± 0.8

99.6 ± 0.9

99.0 ± 1.0

5

101.7 ± 1.0

101.3 ± 0.8

100.6 ± 0.9

100.4 ± 0.9

100.3 ± 0.7

99.9 ± 0.9

99.2 ± 1.1

6

101.9 ± 0.6

101.5 ± 0.9

100.7 ± 1.3

100.5 ± 1.2

100.5 ± 1.3

100.1 ± 1.6

100.0 ± 1.5

 

Statistical results1

None

1 > 3

1 > 3

1 > 3

None

None

None

  1. 1Number of animals for physiological variables measured at a given time point.
  2. 2Includes all statistically significant (p < 0.05) differences between means for treatment groups at a given measurement time point.