From: Multicenter clinical evaluation of a multi-dose formulation of propofol in the dog
Variable | Group | Immediately prior to premedication | Immediately prior to induction | Immediately post-induction | Minutes post-induction | |||
---|---|---|---|---|---|---|---|---|
5 min | 10 min | 20 min | 30 min | |||||
Heart rate (beats per min) (N)1 | 1 | NA (0) | 117.2 ± 32.6 (22) | 118.0 ± 27.1 (21) | 123.7 ± 26.2 (20) | 119.7 ± 28.7 (18) | 112.9 ± 21.4 (10) | 114.8 ± 18.5 (5) |
2 | 113.0 ± 31.0 (25) | 112.8 ± 32.2 (25) | 116.3 ± 36.2 (23) | 110.0 ± 28.7 (21) | 112.1 ± 25.4 (19) | 101.8 ± 26.7 (17) | 94.2 ± 18.5 (14) | |
3 | 107.6 ± 28.9 (25) | 96.9 ± 25.8 (25) | 99.5 ± 34.1 (25) | 101.0 ± 30.7 (23) | 100.3 ± 26.3 (24) | 103.4 ± 22.3 (16) | 99.4 ± 19.1 (7) | |
4 | 127.8 ± 31.3 (22) | 135.9 ± 35.0 (22) | 146.8 ± 28.2 (20) | 146.8 ± 30.9 (19) | 141.7 ± 27.4 (18) | 126.7 ± 26.0 (18) | 123.1 ± 20.1 (19) | |
5 | 116.8 ± 18.9 (22) | 145.1 ± 44.0 (22) | 142.9 ± 37.3 (21) | 158.1 ± 32.0 (20) | 134.2 ± 25.2 (21) | 124.2 ± 23.6 (21) | 114.5 ± 23.4 (20) | |
6 | 115.6 ± 33.5 (21) | 88.4 ± 36.9 (21) | 94.9 ± 27.4 (20) | 104.1 ± 26.3 (19) | 102.6 ± 22.3 (19) | 103.1 ± 20.4 (19) | 95.1 ± 18.8 (18) | |
Statistical results2 | None | 4 > (3, 6); 5 > (2, 3, 6) | 4 > (2, 3, 6); 5 > (3, 6) | 4 > (2, 3, 6); 5 > (1–3, 6) | 4 > (2, 3, 6); 5 > (3, 6) | 4 > (2, 3, 6); 5 > (3, 6) | 4 > (2, 3, 6); 5 > (3, 6) | |
Respiratory rate (breaths per min) | 1 | NA | 41.6 ± 13.8 | 28.6 ± 24.0 | 31.2 ± 16.7 | 32.3 ± 26.6 | 22.6 ± 11.5 | 23.5 ± 9.8 |
2 | 41.1 ± 13.7 | 36.4 ± 14.9 | 26.1 ± 15.5 | 27.1 ± 18.7 | 30.7 ± 19.9 | 32.1 ± 18.4 | 27.0 ± 15.2 | |
3 | 30.6 ± 13.7 | 30.3 ± 13.3 | 23.0 ± 15.2 | 24.6 ± 11.6 | 29.3 ± 11.6 | 27.8 ± 10.8 | 26.4 ± 15.3 | |
4 | 34.8 ± 12.0 | 34.4 ± 11.8 | 23.9 ± 18.8 | 25.7 ± 13.3 | 24.9 ± 19.9 | 23.3 ± 21.7 | 26.5 ± 16.9 | |
5 | 28.6 ± 6.2 | 29.9 ± 17.5 | 12.6 ± 9.8 | 17.4 ± 15.3 | 17.0 ± 11.6 | 14.0 ± 6.3 | 12.6 ± 8.6 | |
6 | 42.4 ± 17.5 | 30.7 ± 23.6 | 12.2 ± 4.5 | 13.8 ± 6.4 | 13.8 ± 7.1 | 14.7 ± 6.7 | 12.9 ± 5.9 | |
Statistical results2 | 6 > 5 | None | 1 > (5, 6) | (1, 2) > 6 | (1, 2, 3) > 6 | (2, 3) > 5; 2 > 6 | (2, 3, 4) > 5; (2, 4) > 6 | |
Systolic blood pressure (mmHg) | 1 | NA | 148.0 ± 28.8 | 128.1 ± 19.9 | 128.2 ± 32.8 | 127.2 ± 21.5 | 115.7 ± 18.2 | 112.8 ± 14.8 |
2 | 141.8 ± 21.3 | 135.0 ± 30.6 | 119.6 ± 24.7 | 113.2 ± 24.0 | 115.3 ± 28.0 | 111.1 ± 20.8 | 115.9 ± 24.4 | |
3 | 136.6 ± 23.4 | 126.2 ± 33.6 | 112.3 ± 21.0 | 108.8 ± 18.5 | 112.2 ± 18.7 | 106.9 ± 17.3 | 106.1 ± 15.5 | |
4 | 129.6 ± 23.1 | 137.4 ± 24.9 | 122.7 ± 21.3 | 108.8 ± 15.3 | 106.4 ± 17.3 | 105.6 ± 26.7 | 108.6 ± 31.8 | |
5 | 137.2 ± 22.3 | 134.5 ± 16.5 | 124.4 ± 15.2 | 112.1 ± 17.1 | 100.9 ± 11.1 | 99.8 ± 14.7 | 101.3 ± 13.7 | |
6 | 137.1 ± 26.6 | 128.9 ± 34.5 | 125.9 ± 40.1 | 116.2 ± 39.4 | 127.9 ± 52.1 | 124.5 ± 36.2 | 116.6 ± 26.3 | |
Statistical results2 | None | None | None | None | (1, 6) > 5 | 6 > 5 | None | |
Diastolic blood pressure (mmHg) | 1 | NA | 91.5 ± 33.6 | 81.1 ± 21.1 | 79.7 ± 32.2 | 82.8 ± 22.6 | 69.4 ± 14.9 | 74.0 ± 23.8 |
2 | 89.0 ± 18.4 | 86.8 ± 22.8 | 77.1 ± 27.5 | 71.2 ± 16.2 | 73.3 ± 19.0 | 71.8 ± 22.9 | 75.1 ± 21.8 | |
3 | 92.4 ± 26.1 | 76.9 ± 27.4 | 70.4 ± 24.0 | 63.5 ± 18.5 | 63.8 ± 15.4 | 57.7 ± 21.3 | 58.7 ± 15.5 | |
4 | 87.1 ± 25.8 | 90.6 ± 28.6 | 76.2 ± 17.2 | 62.9 ± 11.6 | 57.9 ± 15.4 | 57.6 ± 19.8 | 60.6 ± 21.6 | |
5 | 98.8 ± 18.3 | 89.0 ± 17.8 | 74.3 ± 19.0 | 61.3 ± 16.6 | 55.1 ± 4.6 | 53.9 ± 9.1 | 53.2 ± 8.6 | |
6 | 98.4 ± 25.0 | 91.4 ± 31.3 | 90.0 ± 33.6 | 76.8 ± 35.2 | 88.2 ± 44.4 | 79.2 ± 29.2 | 71.8 ± 20.5 | |
Statistical results2 | None | None | None | None | 1 > 5; 6 > (3, 4, 5) | 6 > (3, 4, 5) | (2, 6) > 5 | |
Mean blood pressure (mmHg) | 1 | NA | 114.7 ± 27.1 | 100.2 ± 17.7 | 101.9 ± 31.7 | 99.9 ± 20.8 | 88.1 ± 14.8 | 90.0 ± 21.4 |
2 | 108.9 ± 17.3 | 102.3 ± 21.0 | 95.3 ± 24.2 | 85.8 ± 16.4 | 90.4 ± 26.0 | 87.5 ± 21.2 | 90.4 ± 24.1 | |
3 | 107.8 ± 24.8 | 96.2 ± 27.9 | 86.3 ± 21.3 | 83.7 ± 16.4 | 85.5 ± 13.9 | 78.4 ± 20.7 | 81.1 ± 16.3 | |
4 | 103.7 ± 23.8 | 109.8 ± 25.2 | 94.4 ± 18.7 | 78.0 ± 13.6 | 77.8 ± 15.4 | 76.6 ± 19.1 | 77.8 ± 22.0 | |
5 | 113.1 ± 20.1 | 105.6 ± 14.3 | 92.0 ± 18.0 | 79.7 ± 17.4 | 72.4 ± 8.9 | 69.5 ± 9.5 | 70.3 ± 10.4 | |
6 | 115.1 ± 24.8 | 107.1 ± 31.5 | 105.1 ± 36.2 | 92.6 ± 33.4 | 105.6 ± 44.9 | 99.5 ± 30.5 | 90.9 ± 19.3 | |
Statistical results2 | None | None | None | 1 > (4, 5) | 1 > 5; 6 > (4,5) | 6 > (3, 4, 5) | (2, 6) > 5 | |
Hb Ox Sat (%) | 1 | NA | NA | 90.0 ± 9.9 | 94.3 ± 3.0 | 94.5 ± 2.7 | 95.9 ± 2.2 | 97.3 ± 1.7 |
2 | NA | NA | 90.1 ± 6.7 | 91.8 ± 6.7 | 93.4 ± 3.5 | 94.8 ± 2.7 | 97.7 ± 2.4 | |
3 | NA | NA | 93.9 ± 4.3 | 94.0 ± 3.9 | 94.6 ± 2.7 | 94.8 ± 3.2 | 97.5 ± 2.4 | |
4 | NA | NA | 95.7 ± 2.4 | 95.8 ± 2.1 | 96.7 ± 2.0 | 96.8 ± 1.7 | 95.4 ± 1.8 | |
5 | NA | NA | 96.5 ± 1.9 | 97.6 ± 1.2 | 97.2 ± 1.5 | 97.2 ± 1.8 | 97.0 ± 1.7 | |
6 | NA | NA | 95.6 ± 3.6 | 96.0 ± 2.4 | 95.7 ± 2.6 | 96.5 ± 2.6 | 96.5 ± 2.6 | |
Statistical results2 | - | - | (4, 5, 6) > (1, 2) | (4, 5, 6) > (1, 2) | (4, 5, 6) > 2; 5 > 3 | 5 > (2, 3) | None | |
End-tidal CO2 (%) | 1 | NA | NA | 28.9 ± 7.9 | 31.7 ± 8.3 | 32.5 ± 7.9 | 36.3 ± 5.5 | 40.3 ± 9.2 |
2 | NA | NA | 34.8 ± 12.7 | 34.1 ± 8.0 | 38.2 ± 9.2 | 38.0 ± 9.4 | 40.4 ± 12.2 | |
3 | NA | NA | 31.6 ± 9.9 | 35.9 ± 9.8 | 36.0 ± 7.2 | 37.7 ± 9.6 | 47.0 ± 9.6 | |
4 | NA | NA | 34.6 ± 12.2 | 37.2 ± 9.4 | 36.8 ± 9.9 | 36.6 ± 8.7 | 38.7 ± 5.7 | |
5 | NA | NA | 30.5 ± 7.9 | 33.7 ± 6.3 | 36.5 ± 5.9 | 37.4 ± 4.6 | 38.4 ± 4.4 | |
6 | NA | NA | 37.0 ± 9.2 | 41.4 ± 7.3 | 40.8 ± 9.3 | 42.0 ± 8.0 | 43.8 ± 8.2 | |
Statistical results1 | - | - | None | 6 > 1 | 6 > 1 | None | None | |
Rectal temp. (deg. F) | 1 | NA | 101.7 ± 0.7 | 101.2 ± 0.8 | 100.9 ± 0.9 | 100.4 ± 0.9 | 100.1 ± 1.2 | 99.8 ± 1.0 |
2 | 101.4 ± 0.7 | 101.3 ± 0.7 | 100.8 ± 0.8 | 100.4 ± 0.7 | 100.1 ± 0.7 | 99.8 ± 0.8 | 99.5 ± 0.8 | |
3 | 101.3 ± 0.8 | 100.9 ± 0.7 | 100.3 ± 0.8 | 100.0 ± 1.0 | 99.8 ± 1.3 | 99.5 ± 1.3 | 99.1 ± 1.6 | |
4 | 101.5 ± 0.8 | 101.2 ± 0.7 | 100.3 ± 1.3 | 100.3 ± 0.8 | 100.2 ± 0.8 | 99.6 ± 0.9 | 99.0 ± 1.0 | |
5 | 101.7 ± 1.0 | 101.3 ± 0.8 | 100.6 ± 0.9 | 100.4 ± 0.9 | 100.3 ± 0.7 | 99.9 ± 0.9 | 99.2 ± 1.1 | |
6 | 101.9 ± 0.6 | 101.5 ± 0.9 | 100.7 ± 1.3 | 100.5 ± 1.2 | 100.5 ± 1.3 | 100.1 ± 1.6 | 100.0 ± 1.5 | |
Statistical results1 | None | 1 > 3 | 1 > 3 | 1 > 3 | None | None | None |