Pharmacokinetic/pharmacodynamic modeling for the determination of a cimicoxib dosing regimen in the dog

BMC Veterinary Research

Table 4 Mean plasma half-life and other descriptive statistics of cimicoxib in 4 dogs breeds after a single oral administration of cimicoxib at 2 mg/kg

	Anglo-French hounds	Pointers	Cavalier King Charles spaniels	Bernese mountain dogs
Number of dogs	10	10	10	10
Minimum (h)	2.0	2.5	1.9	3.2
Maximum (h)	4.0	5.9	3.5	5.8
Mean (h)	3.2^a,b	3.9^a,c	2.7^b	4.4^c
Standard Deviation (h)	0.7	1	0.6	0.9
CV (%)	22.7	26.5	21.6	20.1

ISSN: 1746-6148