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Table 3 Pharmacodynamics parameters describing the cimicoxib effect after an oral administration of cimicoxib (2 mg/kg) in 4 poor metabolizers (PM) and 8 extensive metabolizers (EM) dogs

From: Pharmacokinetic/pharmacodynamic modeling for the determination of a cimicoxib dosing regimen in the dog

  EC50or IC50(ng/mL) Emax (no unit) Imax (no unit) Kin (°C.h-1or m.s-1.h-1or score.h-1or normalised force.h-1) Kout (h-1) n (no unit)
  PM EM PM EM PM EM PM EM PM EM PM EM
Body temperature (°C) 473.4 [422.7, 558.9] 193.2 [95.9, 330.0] 0.04 [0.03, 0.04] 0.04 [0.03, 0.06] N.A N.A 45.84 [42.76, 49.19] 41.30 [20.76, 84.13] 1.17 [1.09, 1.25] 1.04 [0.53, 2.10] 6.99 [1.99, 10.00] 5.09 [1.31, 10.00]
Creeping speed (m/s) 344.5 [140.0, 592.7] 239.4 [136.0, 427.5] N.A N.A 0.70 [0.44, 0.87] 0.71 [0.38, 1.00] 0.76 [0.36, 0.97] 0.90 [0.15, 2.71] 1.07 [0.80, 1.47] 0.95 [0.24, 2.02] 3.68 [0.49, 10.00] 4.74 [0.71, 10.00]
Lameness score (no unit) 785.8 [579.4, 916.1] 284.3 [71.1, 827.8] N.A N.A Fixed at 1 Fixed at 1 2.57 [0.70, 4.96] 5.34 [1.17, 16.87] 0.509 [0.14, 0.99] 1.08 [0.22, 3.54] 2.70 [0.66, 5.03] 4.25 [1.12, 10.00]
Vertical force (no unit) 325.1 [235.3, 397.6] 160.8 [51.4, 339.3] N.A N.A 0.97 [0.95, 0.99] 0.98 [0.93, 1.00] 0.09 [0.07, 0.10] 0.09 [0.06, 0.10] 8.47 [5.09, 9.99] 7.40 [3.21, 10.00] 5.67 [4.21, 6.67] 6.13 [2.13, 9.73]
  1. Parameters were estimated using indirect effect PK/PD models. Mean and range, Emax: maximum effect, EC50: plasma concentration to obtain 50% of the Emax, IC50: plasma concentration to obtain 50% of the Imax, Kin: the zero-order rate constant for the production of the response; Kout: the first-order rate constant for the loss of the response; n: coefficient of Hill that measures the slope of the concentration-effect relationship; N.A.: Not Applicable.