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Table 1 Pharmacokinetic parameters (mean ± SD) of cimicoxib administered by the IV route at 2 mg/kg to 12 dogs

From: Pharmacokinetic/pharmacodynamic modeling for the determination of a cimicoxib dosing regimen in the dog

Parameters Extensive metabolizers (n = 8) Poor metabolizers (n = 4)
AUC (h.μg/L) 7202 ± 1814* 19151 ± 3149*
V (L/kg) 1.12 ± 0.203 0.89 ± 0.133
HL (h) 2.72 ± 0.858* 5.63 ± 0.727*
CL (L/h/kg) 0.31 ± 0.118* 0.11 ± 0.022*
  1. Data were analysed using non-compartmental approach; AUC: Area under the curve; V: Volume of distribution; HL: Plasma half- life; Cl: plasma clearance.
  2. *Difference were significant between the two groups p < 0.001 for HL and AUC and p < 0.01 for the CL.