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Figure 5 | BMC Veterinary Research

Figure 5

From: Pharmacokinetic/pharmacodynamic modeling for the determination of a cimicoxib dosing regimen in the dog

Figure 5

Observed ( ● ) and PK/PD predicted (-) effects of cimicoxib vs. time (h) after an oral administration of cimicoxib at 2 mg/kg and observed ( ♦, ●●● ) effects of placebo vs. time (h) for 4 endpoints in a representative poor metabolizer dog. Predicted PK/PD effects were obtain by fitting PD data using an indirect effect model (see Methods for details), for lameness score from 0 (no lameness) to 5 (maximal lameness), see Figure 3 for a definition of the different scoring.

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BMC Veterinary Research

ISSN: 1746-6148

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