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Table 3 Concentration of signalling proteins in different disease categories

From: Interleukin-6, vascular endothelial growth factor and transforming growth factor beta 1 in canine steroid responsive meningitis-arteritis

 

SRMA

SRMA R

SRMA Th

Syst Inflam

ME

CNS-Mix

IE

Healthy

IL-6

CSF

1582

637.7

0

0

3

0

0

3

(pg/mL)

(163.1-3473)

(17.19-1507)

(0–1.5)

(0–31.25)

(0–175.6)

(0–3)

(0–3)

(0.75-3)

Serum

3

17.13

0

17.13

0

0

1.5

3

(pg/mL)

(3–124)

(3–36.24)

(0–0)

(0–77.1)

(0–3)

(0–3)

(0–3)

(0–3)

VEGF

CSF

36.31

20.80

0

0

0

0

0

0

(pg/mL)

(1–175.2)

(0–69.96)

(0–0)

(0–0)

(0–65.71)

(0–0)

(0–0)

(0–0)

Serum

43.92

33.71

3.9

3.9

0

0

0

3.9

(pg/mL)

(3.9-94.5)

(0.98-42.9)

(0–3.9)

(3.9-57.8)

(0–3.9)

(0–3.9)

(0–0)

(1.95-3.9)

TGF-β 1

CSF

90

n.a.

n.a.

n.a.

58

0

n.a.

0

(pg/mL)

(0–429)

   

(0–214)

(0–95)

 

(0–0)

Serum

13.57

n.a.

n.a.

n.a.

22.84

19.31

n.a.

23.84

(ng/mL)

(9.93-19.27)

   

(11.86-27.96)

(14.77-23.25)

 

(18.19-29.16)

  1. IL-6: interleukin-6; VEGF: vascular endothelial grow factor; TGF-β1: Transforming growth factor beta; CSF: cerebrospinal fluid; CNS: central nervous system; SRMA: steroid-responsive meningitis-arteritis; Syst Inflam: systemic inflammatory diseases; ME: other inflammatory CNS diseases; CNS-Mix: miscellaneous non-inflammatory CNS diseases; IE: idiopathic epilepsy; n.a.: not available. Data are given as median and range (25th–75th percentile).