Figure 5
From: The study of the Oxytropis kansuensis-induced apoptotic pathway in the cerebrum of SD rats
Schematic representation of the apoptotic pathway in O. kansuensis -induced SD rat brain cells. Feeding with O. kansuensis Bunge induces apoptosis via the activation of Fas/FasL-mediated pathway and the initiator caspase, caspase-8. Bcl-2 was down-regulated and Bax was up-regulated, activating the mitochondria-mediated apoptotic pathway and causing the activation of caspase-9. Finally, the activation of caspase-8 and -9 activates caspase-3, leading to apoptosis.